- The elimination half-lives have ranged from 1.2 to 7.2 hours after intravenous injection; elimination half-lives after sublingual or transdermal use are longer and may range from 20 to 36 hours or more.
- Buprenorphine is metabolized through N-dealkylation to the pharmacologically active metabolite N-dealkylbuprenorphine (norbuprenorphine) through cytochrome P450 3A4 and by conjugation to glucuronide metabolites.
- The presence of buprenorphine or norbuprenorphine >LOQ indicates exposure to buprenorphine within 7 days.
Approximate Detection Times
|Buprenorphine||LOQ (ng/mL)||Detection Time* up to|