- If there is a question as to a patient's therapeutic compliance, a serum test request for the specific drug of interest may be of help.
- Benzodiazepines are extensively metabolized, and the parent compounds are not detected in urine.
- Diazepam is metabolized to nordiazepam, oxazepam, and temazepam; all may be detected after diazepam
Diazepam → Nordiazepam, Oxazepam, and Temazepam
- Chlordiazepoxide is metabolized to nordiazepam and oxazepam; all may be detected after
Chlordiazepoxide → Nordiazepam and Oxazepam
- Alprazolam is detected as the metabolite α-hydroxyalprazolam.
- Triazolam is detected as the metabolite α-hydroxytriazolam
- Clonazepam is detected as the metabolite 7-aminoclonazepam.
- Flunitrazepam is detected as the metabolite 7-aminoflunitrazepam.
- Flurazepam is detected as the metabolite hydroxyethyl-flurazepam.
Approximate Detection Times
*These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism.
|Benzodiazepines||LOQ (ng/mL)||Detection Time* up to|
|Diazepam as metabolites||100|
|Alprazolam as metabolite||100|
|Chlordiazepoxide as metabolite||100|
|Clonazepam as metabolite||100|
|Flunitrazepam as metabolite||50|
|Triazolam as metabolite||100|
|Flurazepam as metabolite||100|