LYNCH - Overview: Lynch Syndrome Panel

Test Catalog

Test Name

Test ID: LYNCH    
Lynch Syndrome Panel

Useful For Suggests clinical disorders or settings where the test may be helpful

Establishing a diagnosis of Lynch syndrome

 

Identification of familial MLH1, MSH2, MSH6, PMS2, or EPCAM mutations to allow for predictive testing in family members

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

This test includes next-generation sequencing, Sanger sequencing, array comparative genomic hybridization, and multiplex ligation-dependent probe amplification to evaluate for mutations and large deletions/duplications in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Sanger sequencing may also be performed to confirm detected variants.

 

Prior Authorization is available for this assay; see Special Instructions.

Additional Tests Lists test(s) that are always performed, at an additional charge, with the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
COLABHereditary Colon Cancer CGH ArrayYes, (order FMTT)Yes

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Custom Sequence Capture and Targeted Next Generation Sequencing Followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing and Gene Dosage Analysis by Array Comparative Genomic Hybridization (aCGH) or Multiplex Ligation-Dependent Probe Amplification (MLPA)

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Lynch Syndrome Panel

Aliases Lists additional common names for a test, as an aid in searching

Colon Cancer Panel
Colorectal Cancer
EPCAM
Hereditary Cancer Panel
Hereditary Colon Cancer
HNPCC
Juvenile Polyposis syndrome
Lynch syndrome
MLH1
MSH2
MSH6
Next Generation Sequencing
PMS2
Targeted Gene Panel