BRST4 - Overview: Hereditary Breast Cancer 4 Gene Panel

Test Catalog

Test Name

Test ID: BRST4    
Hereditary Breast Cancer 4 Gene Panel

Useful For Suggests clinical disorders or settings where the test may be helpful

Establishing a hereditary susceptibility to cancer

 

Evaluation of families with a history suggestive of a hereditary breast cancer syndrome in which a BRCA1 or BRCA2 gene mutation is not identified

 

Identification of familial TP53, PTEN, CDH1, or STK11 mutation to allow for predictive testing in family members

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test includes next-generation sequencing and array comparative genomic hybridization (aCGH) to evaluate for mutations and large deletions/duplications in the TP53, PTEN (including the promoter), CDH1, and STK11 genes. Sanger sequencing may also be performed to confirm detected variants.

 

Prior Authorization is available for this assay; see Special Instructions.

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Custom Sequence Capture and Targeted Next Generation Sequencing Followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing and Gene Dosage Analysis by Array Comparative Genomic Hybridization (aCGH)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

Hereditary Breast Cancer 4 Gene Panel

Aliases Lists additional common names for a test, as an aid in searching

Breast 4-Gene Panel
Breast Cancer
CDH1
Cowden syndrome
Hereditary Breast Cancer
Hereditary Cancer Panel
Hereditary Diffuse Gastric Cancer
Li-Fraumeni syndrome
Next Generation Sequencing
P53
Petuz-Jeghers syndrome
PTEN
STK11
Targeted Gene Panel
TP53
BRCA