BRCRC - Overview: Hereditary Breast and Colorectal Cancer Panel

Test Catalog

Test Name

Test ID: BRCRC    
Hereditary Breast and Colorectal Cancer Panel

Useful For Suggests clinical disorders or settings where the test may be helpful

Establishing a hereditary susceptibility to cancer

 

Evaluation of families with a history suggestive of a predisposition to both breast and colorectal cancer

 

Identification of familial BRCA1, BRCA2, TP53, PTEN, CDH1, STK11, MLH1, MSH2, MSH6, PMS2, or EPCAM mutation to allow for predictive testing in family members

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test includes next-generation sequencing, Sanger sequencing, array comparative genomic hybridization, and multiplex ligation-dependent probe amplification to evaluate for mutations and large deletions/duplications in the BRCA1, BRCA2, TP53, PTEN (including the promoter), CDH1, STK11, MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Sanger sequencing may also be performed to confirm detected variants.

 

Prior Authorization is available for this assay; see Special Instructions.

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Custom Sequence Capture and Targeted Next Generation Sequencing Followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing and Gene Dosage Analysis by Array Comparative Genomic Hybridization (aCGH) or Multiplex Ligation-Dependent Probe Amplification (MLPA)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

Hereditary Breast/Colon Panel

Aliases Lists additional common names for a test, as an aid in searching

BRCA1
BRCA2
Breast Cancer
Breast and Ovarian Cancer Panel
CDH1
Colon Cancer Panel
Colorectal Cancer
Cowden syndrome
EPCAM
HBOC
Hereditary Breast Cancer
Hereditary Breast and Ovarian Cancer
Hereditary Cancer Panel
Hereditary Colon Cancer
Hereditary Diffuse Gastric Cancer
HNPCC
Li-Fraumeni syndrome
Lynch syndrome
MLH1
MSH2
MSH6
Next Generation Sequencing
Ovarian Cancer
P53
Petuz-Jeghers syndrome
PMS2
PTEN
STK11
Targeted Gene Panel
TP53
BRCA