HCRC - Overview: Hereditary Colon Cancer Multi-Gene Panel

Test Catalog

Test Name

Test ID: HCRC    
Hereditary Colon Cancer Multi-Gene Panel

Useful For Suggests clinical disorders or settings where the test may be helpful

Providing a comprehensive evaluation for hereditary colon cancer in patients with a personal or family history suggestive of a hereditary colon cancer syndrome


Serving as a second-tier test for patients in whom previous targeted gene mutation analyses for specific hereditary colorectal cancer-related genes were negative


Establishing a diagnosis of a hereditary colon cancer syndrome in some cases, allowing for targeted cancer surveillance of associated extra-colonic organs known to be at increased risk for cancer


Identifying mutations within genes known to be associated with increased risk for colon cancer allowing for predictive testing of at-risk family members

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test includes next-generation sequencing, Sanger sequencing, array comparative genomic hybridization, and multiplex ligation-dependent probe amplification to evaluate for the genes listed on the panel.


Prior Authorization is available for this assay; see Special Instructions


See Targeted Gene Regions Interrogated by HCRC / Hereditary Colon Cancer Panel by Next Generation Sequencing in Special Instructions for details regarding the targeted gene regions identified by this test.

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

See Colonic Polyposis Syndromes Testing Algorithm in Special Instructions.

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Custom Sequence Capture and Targeted Next-Generation Sequencing Followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing and Gene Dosage Analysis by Array Comparative Genomic Hybridization (aCGH) or Multiplex Ligation-Dependent Probe Amplification (MLPA)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

Hereditary Colon Cancer Panel

Aliases Lists additional common names for a test, as an aid in searching

Colon Cancer Panel
Colorectal Cancer Panel
Hereditary Cancer Panel
Hereditary Colorectal Cancer
Next Generation Sequencing
Next-Generation Sequencing
Targeted Gene Panel
Targeted-Gene Panel
Next Gen Sequencing Test