BTKMP - Overview: Bruton Tyrosine Kinase (BTK) Genotype and Protein Analysis, Known Mutation Sequencing and Flow Cytometry

Test Catalog

Test Name

Test ID: BTKMP    
Bruton Tyrosine Kinase (BTK) Genotype and Protein Analysis, Known Mutation Sequencing and Flow Cytometry

Useful For Suggests clinical disorders or settings where the test may be helpful

Preferred test for confirming a diagnosis of X-linked agammaglobulinemia (XLA) in male family members of affected individuals with known BTK mutations


Preferred test for determining carrier status of female relatives of male XLA patients with known BTK mutations


By including protein and gene analysis, this test provides a comprehensive assessment and enables appropriate genotype-phenotype correlations.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
BTKKMBTK Gene, Known MutationYes, (order BTKK)Yes
BTKKQBTK Gene, Known Mutation SequencingNoYes
BTKBtk Protein Flow, BYesYes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.


Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

BTKKM: Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

BTK: Flow Cytometry

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

BTK Known Mutation Panel, B

Aliases Lists additional common names for a test, as an aid in searching

B-Cell Progenitor Kinase
Btk (Bruton's Tyrosine Kinase)
Tyrosine Kinase
Tyrosine-Protein Kinase BTK (Bruton's Tyrosine Kinase)
Agammaglobulinemia Tyrosine Kinase