TACIF - Overview: Transmembrane Activator and CAML Interactor (TACI) Gene, Full Gene Analysis

Test Catalog

Test Name

Test ID: TACIF    
Transmembrane Activator and CAML Interactor (TACI) Gene, Full Gene Analysis

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating individuals with:

-Common variable immunodeficiency (CVID)

-Clinically symptomatic selective IgA deficiency

-Lymphoproliferative disease associated with CVID

-Autoimmune phenotypes with CVID


These clinical features may be consistent with possible TACI variants, and the genotyping test is especially useful as a follow-up test when flow cytometry is uninformative.


Identification of specific TACI variants in individuals with abnormal TACI flow cytometry results (from IABCS / B-Cell Phenotyping Profile for Immunodeficiency and Immune Competence Assessment, Blood).

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test uses Sanger sequencing to evaluate for the presence of TNFRSF13B (TACI) variants associated with common variable immunodeficiency (CVID) and other associated conditions.


Targeted testing for familial variants (also called site-specific or known mutation testing) is available for this gene; see KVAR1 / Known Variant Analysis-1 Variant, or KVAR2 / Known Variant Analysis- 2 Variants. Contact Mayo Medical Laboratories at 800-533-1710 to confirm the appropriate test code for targeted testing if testing for more than 2 variants is needed.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
TACISTACI, Full Gene SequenceNoYes
TACITACI Gene SequencingNoYes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.


Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) Followed by DNA Sequence Analysis

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

TACI, Full Gene Sequence

Aliases Lists additional common names for a test, as an aid in searching

Activated T-cells
APRIL receptor
Autoimmune cytopenias
Common variable immunodeficiency
IgA deficiency
Isotype class switching
Malignancy in CVID
T-cell-independent antibody response
Transmembrane Activator and CAML interactor