PYRC - Overview: Pyruvate, Spinal Fluid

Test Catalog

Test Name

Test ID: PYRC    
Pyruvate, Spinal Fluid

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigating possible disorders of mitochondrial metabolism, when used in conjunction with cerebrospinal fluid lactate collected at the same time to determine the lactate-to-pyruvate ratio


Evaluating patients with neurologic dysfunction and normal blood lactate-to-pyruvate ratios

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

The CSF lactate:pyruvate (L:P) ratio is considered a helpful (not diagnostic) tool in the evaluation of patients with possible disorders of mitochondrial metabolism, especially in patients with neurologic dysfunction and normal blood L:P ratios. Pyruvic acid levels alone have little clinical utility.

Method Name A short description of the method used to perform the test

Spectrophotometry (SP)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Pyruvic Acid, CSF

Aliases Lists additional common names for a test, as an aid in searching

Mitochondrial Electron Transport Chain Defects
Mitochondrial Respiratory Chain Disorders
PDH (Pyruvate Dehydrogenase) Deficiency
PDHC (Pyruvate Dehydrogenase Complex)
Pyruvate Carboxylase Deficiency
Pyruvate Dehydrogenase (PDH) Deficiency
Pyruvate Dehydrogenase Complex (PDHC)
Lactate to Pyruvate Ratio (lactate [test ID ZW10] must be ordered separately on the same spinal fluid)