LUPPR - Overview: Lupus Anticoagulant Profile

Test Catalog

Test Name

Test ID: LUPPR    
Lupus Anticoagulant Profile

Useful For Suggests clinical disorders or settings where the test may be helpful

Confirming or excluding presence of lupus anticoagulant (LAC) distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors


Investigation of a prolonged activated thromboplastin time, especially when combined with other coagulation studies

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
PTCProthrombin Time (PT), PYes, (order PTTP)Yes
APTTBActivated Partial Thrombopl Time, PYes, (order APTTP)Yes
DRVTDilute Russells Viper Venom Time, PYes, (Order DRVTI)Yes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests

Test IDReporting NameAvailable SeparatelyAlways Performed
DIRMD-Dimer, PYes, (order #9290)No
IBETHBethesda UnitsNoNo
F8ISCoag Factor VIII Assay Inhib Scrn,PNoNo
FACTVCoag Factor V Assay, PYesNo
F_7Coag Factor VII Assay, PYesNo
TTThrombin Time (Bovine), PYesNo
F_9Coag Factor IX Assay, PYesNo
F_10Coag Factor X Assay, PYesNo
F_11Coag Factor XI Assay, PYesNo
F_12Coag Factor XII Assay, PYesNo
F8ACoag Factor VIII Activity Assay, PYesNo
RPTLReptilase Time, PYesNo
F_2Coag Factor II Assay, PYesNo
FIBCFibrinogen, PYes, (order #8484)No
SFMSoluble Fibrin MonomerNoNo
PNPPlatelet Neutralization ProcedureNoNo
PTMXPT Mix 1:1NoNo
DRVTCDRVVT ConfirmationNoNo
CCC2Special Coagulation InterpretationNoNo
STLAStaclot LA, PNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Initial testing includes: prothrombin time (PT), activated partial thromboplastin time (APTT), and dilute Russell's viper venom time (DRVVT).

If the PT, APTT, and DRVVT are normal, a computer-generated interpretive comment indicating no evidence of a lupus anticoagulant will be provided.

If PT is > or =14 seconds, PT mix will be performed.

If APTT is >36 seconds, APTT mix will be performed.

If APTT mix is >36 seconds with no evidence of heparin in sample, platelet neutralization procedure (PNP) will be performed.

If DRVVT ratio is > or =1.2, DRVVT mix and DRVVT confirmation will be performed.

If PT, APTT, or DRVVT are prolonged, thrombin time (TT) will be performed.

If TT is >23 seconds, reptilase will be performed.

If appropriate, coagulation factor assays, fibrinogen, D-dimer, Staclot LA, and soluble fibrin monomer will be performed to clarify a significant abnormality in the screening clotting times.

If factor VIII result is <55%, the factor VIII inhibitor screen may be performed along with the Bethesda titering assay, if indicated.

If any test results are abnormal, all results will be reviewed by a coagulation consultant and a Special Coagulation Consultant Interpretation will be provided.


See Lupus Anticoagulant Profile Testing Algorithm in Special Instructions.

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test


DIRM: Automated Latex Immunoassay (LIA)

PNP: Activated Partial Thromboplastin Time (APTT) Mixing Test

F_2, FACTV, F_7, F_10, IBETH, F8IS: Prothrombin Clot-Based Assay

F8A, F_9, F_11, F_12: Activated Partial Thromboplastin Clot-Based Assay

FIBC: Clauss Methodology

SFM: Immunoturbidimetric

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

Lupus Anticoag Prof

Aliases Lists additional common names for a test, as an aid in searching

APTT Mixing Studies
Dilute Russell Viper Venom Time (DRVVT)
DRVVT (Dilute Russell Viper Venom Time)
Phospholipid Antibodies
Platelet Neutralization Procedure (PNP Coag Consult)