HPFH - Overview: Hemoglobin F, Red Cell Distribution, Blood

Test Catalog

Test Name

Test ID: HPFH    
Hemoglobin F, Red Cell Distribution, Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Distinguishing large deletional hereditary persistence of fetal hemoglobin from other conditions with increased percentage of fetal hemoglobin


Determining the distribution of Hb F within red blood cells

Additional Tests Lists tests that are always performed, at an additional charge, with the initial tests

Test IDReporting NameAvailable SeparatelyAlways Performed
HBFHemoglobin F, BNoYes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

The percent of the patient's hemoglobin F is very important to the clinical utility of this test. HBF / Hemoglobin F, Blood will be performed at an additional charge to determine if Hemoglobin F, Red Cell Distribution testing is warranted. If the hemoglobin F value is normal for age or if the value is less than 5%, the red cell distribution test will not be performed. Samples with hemoglobin F (Hb F) levels above 35% will be accepted but are discouraged due to decreased test specificity. For these markedly elevated Hb F levels, a hemoglobin electrophoresis profile with request for beta globin gene molecular testing for elevated Hb F levels is recommended.


For information on thalassemias and appropriate test ordering, see Thalassemia/Hemoglobinopathy Patient Information in Special Instructions.

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Flow Cytometry

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Hemoglobin F, Red Cell Distrib, B

Aliases Lists additional common names for a test, as an aid in searching

Acid Elution Test for Fetal Hgb
Fetal Hemoglobin
Hemoglobin F, Red Cell Distribution, Blood - NOT FOR MATERNAL BLEED