MPSS - Overview: Monoclonal Protein Study, Serum

Test Catalog

Test Name

Test ID: MPSS    
Monoclonal Protein Study, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis of monoclonal gammopathies, when used in conjunction with urine monoclonal studies


Monitoring patients with monoclonal gammopathies


Protein electrophoresis alone is not considered an adequate screen for monoclonal gammopathies

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
TPETotal ProteinYes, (order TP)Yes
ELPProtein ElectrophoresisNoYes
IMFXImmunofixationYes, (order IMFXO)Yes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Includes total protein, serum protein electrophoresis (SPEP), heavy chain and light chain typing (kappa and lambda).


The following algorithms are available in Special Instructions:

-Laboratory Approach to the Diagnosis of Amyloidosis

-Laboratory Screening Tests for Suspected Multiple Myeloma

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

TPE: Biuret

ELP: Agarose Gel Electrophoresis

IMFX: Immunofixation

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

Monoclonal Protein Study, S

Aliases Lists additional common names for a test, as an aid in searching

Immunoelectrophoresis, Serum
Immunofixation Electrophoresis (IFE)
Immunofixation, Serum
MGUS (Monoclonal Gammopathy of Unknown Significance)
Multiple Myeloma
Special Protein Studies
IFE (Immunofixation Electrophoresis)