MPNCM - Overview: Myeloproliferative Neoplasm (MPN), CALR with Reflex to MPL

Test Catalog

Test Name

Test ID: MPNCM    
Myeloproliferative Neoplasm (MPN), CALR with Reflex to MPL

Useful For Suggests clinical disorders or settings where the test may be helpful

Aiding in the distinction between a reactive cytosis and a myeloproliferative neoplasm when JAK2V617F testing result is negative

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
MPNMLMPL Exon 10 Sequencing, ReflexNo, (bill only)No

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

This test reflexively evaluates for mutations in the CALR and MPL genes commonly associated with BCR/ABL1-negative myeloproliferative neoplasms. The testing sequence is based on the reported frequency of gene mutations in this disease group. It is usually ordered when a JAK2 V617F result is known to be negative. Initial testing evaluates for the presence of the CALR indels. If out-of-frame CALR indels are detected, the testing algorithm ends. If the CALR result is negative or an in-frame CALR indel is identified, then testing proceeds, at an additional charge, to evaluate for mutations in exon 10 of the MPL gene by Sanger sequencing. An integrated report is issued with the summary of test results.

 

The following algorithms are available in Special Instructions:

-Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood

-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) and Fragment Analysis

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

MPN (CALR, MPL) Reflex

Aliases Lists additional common names for a test, as an aid in searching

CALR
Essential Thrombocythemia
JAK2-negative Myeloproliferative Neoplasm
Janus kinase 2 gene
MPL S505
MPL W515
Myelofibrosis
Myeloproliferative Disorder
Myeloproliferative leukemia virus oncogene
Myeloproliferative Neoplasm (MPN)
Primary Myelofibrosis
Tyrosine Kinase Mutation
Calreticulin