ADALX - Overview: Adalimumab Quantitative with Reflex to Antibody, Serum

Test Catalog

Test Name

Test ID: ADALX    
Adalimumab Quantitative with Reflex to Antibody, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Detection and quantification of antibodies directed against adalimumab in human serum

 

Trough level quantitation for evaluation of patients with loss of response to adalimumab

Highlights

Adalimumab (trade name Humira, manufactured by AbbVie) is a fully human therapeutic monoclonal antibody targeting tumor necrosis factor alpha (TNF), a proinflammatory cytokine that is upregulated in several autoimmune inflammatory states.

 

Adalimumab is FDA-approved for treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis; ankylosing spondylitis, pediatric and adult Crohn disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa and uveitis. Adalimumab is a subcutaneous injection, usually self-administered every other week at a fixed dose of 40 mg in adults, although dosing can vary.

 

Testing for adalimumab concentration and presence of anti-adalimumab antibodies is helpful to adjust therapeutic strategies for patients starting therapy (proactive monitoring), and to adjust dosing when partial response or loss of response to therapy is observed, manifested as recurrence of symptoms.

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
ADLABAdalimumab Ab, SNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If the result is 5.0 mcg/mL or less, the adalimumab antibody test will be performed at an additional charge.

Method Name A short description of the method used to perform the test

Enzyme-Linked Immunosorbent Assay (ELISA)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Adalimumab QN with Reflex to Ab, S

Aliases Lists additional common names for a test, as an aid in searching

Humira