NGSAM - Overview: Next-Generation Sequencing (NGS), Acute Myeloid Leukemia

Test Catalog

Test Name

Test ID: NGSAM    
Next-Generation Sequencing (NGS), Acute Myeloid Leukemia

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluation of acute myeloid leukemia (AML) at the time of diagnosis, to assist in appropriate classification and prognosis using a 19-gene panel

 

Evaluation to determine if a different gene mutation profile is present at the time of AML relapse

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

This test includes next-generation sequencing to evaluate for the following 19 genes: ASXL1, BCOR, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, KIT, NPM1, PHF6, RUNX1, SF3B1, SRSF2, TET2, TP53, U2AF1, WT1, and ZRSR2.

Highlights

Next-generation sequencing detection of somatic gene mutations, including type, pattern, and distribution, has diagnostic, prognostic, and potential therapeutic implications for patients with hematologic cancers.

 

This test enables more accurate classification of acute myeloid leukemias (AML).

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

See Targeted Genes Interrogated by Acute Myeloid Leukemia by Next-Generation Sequencing in Special Instructions for a list of the genes and exons targeted by this test.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Somatic Mutation Detection by Next-Generation Sequencing (NGS), Hematologic Neoplasms

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

NGS Acute Myeloid Leukemia

Aliases Lists additional common names for a test, as an aid in searching

Next gen sequencing of leukemia
NGS for acute myeloid leukemia evaluation
NGS hematologic malignancies
Somatic mutation detection by next generation sequencing (NGS), hematologic
ASXL1
BCOR
CEBPA
DNMT3A
EZH2
FLT3
IDH1
IDH2
NPM1
PHF6
RUNX1
SF3B1
SRSF2
TET2
U2AF1
WT1
ZRSR2
Next Gen Sequencing Test
KIT
TP53