MGRM - Overview: Myasthenia Gravis (MG) Evaluation with MuSK Reflex, Serum

Test Catalog

Test Name

Test ID: MGRM    
Myasthenia Gravis (MG) Evaluation with MuSK Reflex, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis for autoimmune myasthenia gravis in adults and children

 

Distinguishing autoimmune from congenital myasthenia gravis in adults and children

 

Establishing a quantitative baseline value that allows comparison with future levels if weakness is worsening

Highlights

Seropositivity confirms a clinical or electrophysiologic diagnosis of autoimmune myasthenia gravis (MG).

 

Second-line muscle-specific kinase (MuSK) antibody test positivity confirms a clinical or electrophysiologic diagnosis of autoimmune MG where first-line serological tests acetylcholine receptor: AChR binding and modulating antibodies) are negative.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
MGRMIMG Interpretive CommentsNoYes
ARBIACh Receptor (Muscle) Binding AbYesYes
STRStriational (Striated Muscle) Ab, SYesYes
ARMOACh Receptor (Muscle) Modulating AbNoYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
MUSKMuSK Autoantibody, SYesNo
GD65SGAD65 Ab Assay, SYesNo
CRMWSCRMP-5-IgG Western Blot, SNoNo
GANGAChR Ganglionic Neuronal Ab, SNoNo
VGKCNeuronal (V-G) K+ Channel Ab, SNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If acetylcholine receptor (AChR) modulating antibodies are > or =90% and striational antibodies are > or =1:120, then AChR ganglionic neuronal autoantibody, glutamic acid decarboxylase autoantibody, neuronal voltage-gated potassium channel autoantibody, and CRMP-5-IgG Western blot will be performed at an additional charge.

 

If AChR binding antibodies are < or = to 0.02 and AChR modulating antibodies are < or = 20%, then muscle-specific kinase (MuSK) autoantibody will be performed at an additional charge.

 

See Myasthenia Gravis Evaluation with MuSK Reflex Algorithm in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

ARBI, ARMO, GANG, VGKC: Radioimmunoassay (RIA)

STR: Enzyme Immunoassay (EIA)

CRMWS: Western Blot

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

N/A

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

MG Evaluation with MuSK Reflex, S

Aliases Lists additional common names for a test, as an aid in searching

Acetylcholine Receptor (Muscle AChR) Antibodies
Ach Receptor Ab
AChR Receptor Blocking Ab
AChR (Acetylcholine Receptor)
Anti-Skeletal Muscle Antibodies
Binding, Blocking, and Modulating Abs
Blocking Ab
GAD65 (Glutamic Acid Decarboxylase)
Glutamate Decarboxylase Antibodies (GAD65)
Muscle End-Plate Antibodies
Myasthenia Gravis
Myasthenia Gravis Antibodies
MuSK myasthenia
Myoid Antibody
Neuronal Potassium Channel Ab
Potassium Channel Antibodies (specify)
Thymoma
VGKC
VGPC
Voltage-Gated Potassium Channel Ab
MUSK