MUSK - Overview: Muscle-Specific Kinase (MuSK) Autoantibody, Serum

Test Catalog

Test Name

Test ID: MUSK    
Muscle-Specific Kinase (MuSK) Autoantibody, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis of autoimmune muscle-specific kinase (MuSK) myasthenia gravis

 

Second-order test to aid in the diagnosis of autoimmune myasthenia gravis when first-line serologic tests are negative

 

Establishing a quantitative baseline value for MuSK antibodies that allows comparison with future levels if weakness is worsening

Highlights

Second-line test aiding diagnosis of autoimmune myasthenia gravis (MG) in patients with new onset acquired MG evident clinically and electrophysiologically but negative first-line serological tests (acetylcholine receptor: AChR binding and modulating antibodies).

 

A positive result, in the appropriate clinical context, confirms the diagnosis of autoimmune muscle-specific kinase myasthenia gravis.

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

See Myasthenia Gravis Evaluation with MuSK Reflex Algorithm in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Radioimmunoassay (RIA)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

MuSK Autoantibody, S

Aliases Lists additional common names for a test, as an aid in searching

MuSK