NIPS - Overview: Cell-Free DNA Prenatal Screen

Test Catalog

Test Name

Test ID: NIPS    
Cell-Free DNA Prenatal Screen

Important: Mayo Medical Laboratories is licensed to perform NIPS testing only for clients located in the North and South American continents. If you reside outside of this authorized region, contact an alternative provider to perform similar testing.

Useful For Suggests clinical disorders or settings where the test may be helpful

Noninvasive screening for aneuploidies of chromosomes 13, 18, and 21 in pregnancies

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

This is noninvasive prenatal screening for aneuploidies in pregnancies.

 

Prior Authorization is available for this assay; see Special Instructions.

Highlights

This is a screening test for pregnant patients for fetal aneuploidy.

 

Previously published data using similar methods indicates that this test is expected to have an approximate positive predictive value of 94% for trisomy 21 in high-risk populations. Positive predictive value is lower for the detection of trisomy 18 (60%), and lower still for trisomy 13 (44%). Negative predictive value is greater than 99% for trisomy 21, trisomy 18, and trisomy 13 in high-risk populations.

 

Noninvasive prenatal screening is not diagnostic; thus, abnormal results should be confirmed with invasive prenatal diagnostic testing, and a genetic consultation is recommended.

 

A negative result does not ensure an unaffected pregnancy.

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

This test is only available to clients in North and South America.

 

When this test is ordered, additional statistical analysis to determine the percentage of fetal DNA present is always performed.

 

The following algorithms are available in Special Instructions:

-Prenatal Aneuploidy Screening and Diagnostic Testing Options

-High-Risk Pregnancy Based on Abnormal Fetal Malformations: Laboratory Testing Algorithm

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Whole Genome Sequencing of Plasma Cell-Free DNA

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Submitted

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Cell-Free DNA Prenatal Screen

Aliases Lists additional common names for a test, as an aid in searching

NIPS
NIPT
Noninvasive prenatal screening
Noninvasive prenatal testing
Trisomy 21
Trisomy 18
Trisomy 13
Prenatal screening
Next Gen Sequencing Test
cell free
cfDNA
cffDNA