CALR - Overview: CALR Mutation Analysis, Myeloproliferative Neoplasm (MPN)

Test Catalog

Test Name

Test ID: CALR    
CALR Mutation Analysis, Myeloproliferative Neoplasm (MPN)

Useful For Suggests clinical disorders or settings where the test may be helpful

Rapid and sensitive detection of insertion and deletion-type mutations in exon 9 of CALR


An aid in distinction between reactive thrombocytosis and leukocytosis versus a myeloproliferative neoplasm (MPN), especially essential thrombocythemia (ET) and primary myelofibrosis (PMF), and is highly informative in cases in which JAK2 and MPL testing are negative


Especially helpful to the pathologist in those bone marrow cases with ambiguous etiology of thrombocytosis, equivocal bone marrow morphologic findings of MPN, and unexplained reticulin fibrosis


An aid in prognostication of PMF and thrombosis risk assessment in ET

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

The following algorithms are available in Special Instructions:

-Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood

-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test.

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) and Fragment Analysis

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

MPN, CALR Gene Mutation, Exon 9

Aliases Lists additional common names for a test, as an aid in searching

Myeloproliferative Neoplasm (MPN)
Myeloproliferative Disorder
Essential Thrombocythemia
Primary Myelofibrosis
JAK2-negative Myeloproliferative Neoplasm