ENFD - Overview: Epidermal Nerve Fiber Density Consult

Test Catalog

Test Name

Test ID: ENFD    
Epidermal Nerve Fiber Density Consult

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigation of polyneuropathies

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests

Test IDReporting NameAvailable SeparatelyAlways Performed
NPWTNervePath, Level IV, Wet TsNo, (Bill Only)No
NPOSNervePath Consult, Outside SlideNo, (Bill Only)No
NPSPNervePath Consult, w/Slide PrepNo, (Bill Only)No
NPUPNervePath Consult, w/USS ProfNo, (Bill Only)No
NPCHXNervePath Consult, w/Comp Rvw of HxNo, (Bill Only)No
MORANMorphometric AnalysisNo, (Bill Only)No
CREDCongo Red, Nrv STNo, (Bill Only)No
PNS1IHC Initial Single Antibody StainNo, (Bill Only)No
PNS2IHC, Each Add'l Antibody StainNo, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, 1 or more of the listed reflex tests will be performed and charged for each biopsied site.


Wet tissue for consultation: When adequately prepared tissue is provided, routine testing will include: PGP 9.5 immunostain, morphometric analysis, Congo red stain, and hematoxylin and eosin stain.


Slides and blocks sent for consultation must include PGP 9.5 reacted sections:

Special stains and studies performed on the case should be sent with the case for review. In order to determine an accurate diagnosis, some of these stains or studies may be deemed to warrant repeat testing at an additional charge at the discretion of the reviewing Mayo Clinic neuromuscular pathologist. In addition, testing requested by the referring physician (immunostains, molecular studies, etc) may not be performed if deemed unnecessary by the reviewing Mayo Clinic neuromuscular pathologist. For all consultations, ancillary testing necessary to determine a diagnosis is ordered at the discretion of the Mayo Clinic neuromuscular pathologist. An interpretation, which includes an evaluation of the specimen and determination of a diagnosis, will be provided within a formal pathology report.

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Calculation of Epidermal Nerve Fiber Density from Skin Punch Biopsy 

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

Epidermal Nerve Fiber Density

Aliases Lists additional common names for a test, as an aid in searching

Skin punch biopsy
Small fiber neuropathy