CMAP - Overview: Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling

Test Catalog

Test Name

Test ID: CMAP    
Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling

Useful For Suggests clinical disorders or settings where the test may be helpful

Prenatal diagnosis of copy number changes (gains or losses) across the entire genome

 

Determining the size, precise breakpoints, gene content, and any unappreciated complexity of abnormalities detected by other methods such as conventional chromosome and FISH studies

 

Determining if apparently balanced abnormalities identified by previous conventional chromosome studies have cryptic imbalances, since a proportion of such rearrangements that appear balanced at the resolution of a chromosome study are actually unbalanced when analyzed by higher-resolution chromosomal microarray

 

Assessing regions of homozygosity related to uniparental disomy or identity by descent

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

Cultures from this specimen will be discarded 10 days after all cytogenetic test results have been reported. If further testing is desired, call the laboratory at 507-284-1668.

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

A maternal blood sample is requested when ordering this test (see PPAP / Parental Sample Prep for Prenatal Microarray Testing); the PPAP test must be ordered under a different order number than the prenatal specimen.

 

Maternal cell contamination (MCC) testing will be performed at no additional charge on the maternal blood and fetal tissue to rule out the presence of maternal cells in the product of conception sample.

 

A paternal blood sample is desired but not required (see PPAP / Parental Sample Prep for Prenatal Microarray Testing).

 

If an insufficient sample is received or MCC is identified in the prenatal sample, microarray testing will be performed on cultured material.

 

Portions of the specimen may be used for other tests such as measuring markers for neural tube defects (eg, AFPA / Alpha-Fetoprotein, Amniotic Fluid), molecular genetic testing, biochemical testing, and chromosome and FISH testing (including CHRAF / Chromosome Analysis, Amniotic Fluid; CHRCV / Chromosome Analysis, Chorionic Villus Sampling; and PADF / Prenatal Aneuploidy Detection, FISH).

 

The following algorithms are available in Special Instructions:

-Prenatal Aneuploidy Screening and Diagnostic Testing Options

-High-Risk Pregnancy Based on Abnormal Fetal Malformations: Laboratory Testing Algorithm

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Chromosomal Microarray (CMA) Using Affymetrix Cytoscan HD

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Chromosomal Microarray, Prenatal

Aliases Lists additional common names for a test, as an aid in searching

Oligonucleotide Array
Oligo Array
Single Nucleotide Polymorphism (SNP) Array
Whole Genome Array
Molecular Karyotype
Constitutional Array
Prenatal Diagnosis
aCGH or array CGH (Array Comparative Genomic Hybridization)
Amniotic fluid
Chorionic villi sample or CVS