TP53Z - Overview: TP53 Gene, Full Gene Analysis

Test Catalog

Test Name

Test ID: TP53Z    
TP53 Gene, Full Gene Analysis

Useful For Suggests clinical disorders or settings where the test may be helpful

Confirmation of suspected clinical diagnosis of Li-Fraumeni syndrome or Li-Fraumeni-like syndrome


Identification of familial TP53 mutation to allow for predictive testing in family members

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test evaluates for the presence of germline TP53 mutations associated with Li Fraumeni syndrome. For patients with a history of hematologic malignancy and/or bone marrow transplant, consultation with the laboratory is required prior to submitting a specimen.


Note: This test is NOT appropriate for evaluation of somatic TP53 mutations. To evaluate for the presence of somatic TP53 mutations for diagnostic or prognostic purposes in patients with chronic lymphocytic leukemia, see P53CA / Hematologic Neoplasms, TP53 Somatic Mutation, DNA Sequencing Exons 4-9

Additional Tests Lists tests that are always performed, at an additional charge, with the initial tests

Test IDReporting NameAvailable SeparatelyAlways Performed
COLABHereditary Colon Cancer CGH ArrayYes, (order FMTT)Yes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, comparative genomic hybridization array will always be performed at an additional charge.


See TP53 Mutation Testing Analysis in Special Instructions.

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) Amplification Followed by DNA Sequencing and Gene Dosage Analysis by Array Comparative Genomic Hybridization (aCGH)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

TP53 Gene, Full Gene Analysis

Aliases Lists additional common names for a test, as an aid in searching

Li-Fraumeni syndrome
Li-Fraumeni-like syndrome
SBLA syndrome