IHC - Overview: Mismatch Repair (MMR) Protein Immunohistochemistry Only, Tumor

Test Catalog

Test Name

Test ID: IHC    
Mismatch Repair (MMR) Protein Immunohistochemistry Only, Tumor

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluation of tumor tissue to identify patients at risk for having hereditary nonpolyposis colon cancer/Lynch syndrome

Note: Mayo's preferred screening test, MSIHC / Microsatellite Instability (MSI)/Immunohistochemistry (IHC) Profile-Lynch/Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Screen, includes both microsatellite instability and immunohistochemistry testing.

Additional Tests Lists test(s) that are always performed, at an additional charge, with the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
MSH2IMSH-2, ImmunostainNo, (bill only)Yes
MSH6IMSH-6, ImmunostainNo, (bill only)Yes
PMS2IPMS-2, ImmunostainNo, (bill only)Yes
MLH1IMLH-1, ImmunostainNo, (bill only)Yes

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, MLH1, MSH2, MSH6, and PMS2 stains will always be performed at an additional charge.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Immunohistochemical Staining

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

MMR Protein, IHC Only, Tumor

Aliases Lists additional common names for a test, as an aid in searching

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
HNPCC testing
Immunohistochemistry (IHC)
Lynch syndrome
Mismatch Repair (MMR) Protein Immunohistochemistry