CHRBM - Overview: Chromosome Analysis, Hematologic Disorders, Bone Marrow

Test Catalog

Test Name

Test ID: CHRBM    
Chromosome Analysis, Hematologic Disorders, Bone Marrow

Useful For Suggests clinical disorders or settings where the test may be helpful

Assisting in the diagnosis and classification of certain malignant hematological disorders


Evaluating the prognosis in patients with certain malignant hematologic disorders


Monitoring effects of treatment


Monitoring patients in remission

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests

Test IDReporting NameAvailable SeparatelyAlways Performed
_ML20Metaphases, 1-19No, (Bill Only)No
_M25Metaphases, 20-25No, (Bill Only)No
_MG25Metaphases, >25No, (Bill Only)No
_STACAg-Nor/CBL StainNo, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test includes a charge for cell culture of fresh specimens and professional interpretation of results. Analysis charges will be incurred for total work performed, and generally include 2 banded karyograms and the analysis of 20 metaphase cells. If no metaphase cells are available for analysis, no analysis charges will be incurred. If additional analysis work is required, additional charges may be incurred.


The following algorithms are available in Special Instructions:

-Acute Promyelocytic Leukemia: Guideline to Diagnosis and Follow-up

-B-Lymphoblastic Leukemia/Lymphoma Algorithm

-Myelodysplastic Syndrome: Guideline to Diagnosis and Follow-up

-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation

-Malignant Lymphoma, Guideline for Bone Marrow Staging Studies

-Laboratory Screening Tests for Suspected Multiple Myeloma

Special Instructions and Forms Library of PDFs including pertinent information and consent forms, specimen collection and preparation information, test algorithms, and other information pertinent to test

Method Name A short description of the method used to perform the test

Cell Culture without Mitogens* followed by Chromosome Analysis


*In addition to the cell culture without mitogens, a CpG-stimulated culture will be added and 10 additional cells will be analyzed for any specimen received from a patient age 30 or older with a reason for referral of chronic lymphocytic leukemia, small lymphocytic leukemia, lymphocytosis, Waldenstrom macroglobulinemia, or when test CLLF / Chronic Lymphocytic Leukemia (CLL), FISH is ordered concurrently.

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter or abbreviated version of the Published Name for a test; an abbreviated test name

Chromosomes, Hematologic, BM

Aliases Lists additional common names for a test, as an aid in searching

Karyotype, Bone Marrow