GPI - Clinical: Glucose Phosphate Isomerase, Erythrocytes

Test Catalog

Test Name

Test ID: GPI    
Glucose Phosphate Isomerase, Erythrocytes

Useful For Suggests clinical disorders or settings where the test may be helpful

A second-order test in the evaluation of individuals with chronic hemolysis

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Erythrocyte glucose phosphate isomerase (GPI) deficiency has been reported as a cause of chronic hemolysis in numerous cases. Inheritance is autosomal recessive. Hemolytic disease of the newborn is a common presenting manifestation of GPI deficiency.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

> or =12 months: 39.3-57.7 U/g Hb

Reference values have not been established for patients who are <12 months of age.

Interpretation Provides information to assist in interpretation of the test results

Glucose phosphate isomerase (GPI) deficiency causes a moderately severe anemia. GPI values can be 25% of normal.


Increased GPI activity may be seen when young red blood cells are being produced in response to the anemia (reticulocytosis) or in the case of a newborn.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

Fairbanks VF, Klee GG: Biochemical aspects of hematology. In Tietz Textbook of Clinical Chemistry. Third Edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB Saunders Company, 1999, pp 1642-1646