FSLAA - Clinical: Soluble Liver Antigen (SLA) Autoantibody

Test Catalog

Test Name

Test ID: FSLAA    
Soluble Liver Antigen (SLA) Autoantibody

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Reference Range:          Negative           0.0 – 20.0 U

                                    Equivocal         20.1 – 24.9 U

                                    Positive            >25.0 U

 

Antibodies to soluble liver antigen (SLA) appear to be directed against the UGA-suppressor tRNA associated protein. These antibodies are highly specific for autoimmune hepatitis (AIH) and may rarely, be the only autoantibodies detected in serum from such patients. Antibodies  to SLA are most closely associated with AIH type 1; the presence of these antibodies  in patients with cryptogenic hepatitis suggests that these patients may have AIH type 1.

 

Anti-SLA antibodies may be detected in some patients with the primary biliary cirrhosis-AIH overlap syndrome, but not in healthy controls.