Test ID: EEST
Estradiol, Serum
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Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
CHILDREN*
1-14 days: Estradiol levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
| Tanner Stages# | Mean Age | Reference Range |
| Stage I (>14 days and prepubertal) | 7.1 years | Undetectable-13 pg/mL |
| Stage II | 12.1 years | Undetectable-16 pg/mL |
| Stage III | 13.6 years | Undetectable-26 pg/mL |
| Stage IV | 15.1 years | Undetectable-38 pg/mL |
| Stage V | 18 years | 10-40 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys, there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
| Tanner Stages# | Mean Age | Reference Range |
| Stage I (>14 days and prepubertal) | 7.1 years | Undetectable-20 pg/mL |
| Stage II | 10.5 years | Undetectable-24 pg/mL |
| Stage III | 11.6 years | Undetectable-60 pg/mL |
| Stage IV | 12.3 years | 15-85 pg/mL |
| Stage V | 14.5 years | 15-350 pg/mL** |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data, and on our data for young adults.
ADULTS
Males: 10-40 pg/mL
Females
Premenopausal: 15-350 pg/mL**
Postmenopausal: <10 pg/mL
**E2 levels vary widely through the menstrual cycle.
Conversion factor
E2: pg/mL x 3.676=pmol/L (molecular weight=272)
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