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Age-Matched Referenced Values
Provision of age-matched reference values is critical for the proper care of pediatric patients. Mayo Medical Laboratories is committed to providing the most accurate reference values possible. Children are not small adults. Their test results may vary significantly from adults or even from children of different ages based on their stage of biological development.
Ongoing Pediatric Initiative
Tests and method changes include specific pediatric reference values when appropriate. This continuing effort is a result of a pediatric initiative begun in 2005, when the Department of Laboratory Medicine and Pathology at Mayo Clinic conducted a comprehensive review of pediatric reference values for laboratory tests.
Types of Reference Values Provided
- Mayo-derived pediatric reference values that are based on age, and in some cases, Tanner classification.
- Reference values that apply to all ages are designated as such.
- Literature-derived pediatric values (citations provided).
Values are Based on the Following Information
Mayo-derived pediatric reference values generated from:
- Large numbers of pediatric specimens, at least 120 per age or gender strata
- Subject populations who have undergone clinical puberty staging, using the Tanner classification (such Tanner-stratified studies can require up to 1,000 specimens to complete the evaluation)
- Disease-classified (including medications, medical history) specimens, which allows exclusion of samples from patients who suffer from conditions that are likely to affect the levels of the analyte for which pediatric values are being generated.
An exhaustive literature review:
- Determining if published studies provide useful and reliable interpretive guidance based on analytic method comparability, patient selection criteria and sample size, specimens employed, and statistical tools used.
- In most instances, such literature-based values are also backed by additional validation data, such as a method comparison between the published method and the method used by Mayo’s laboratories.