Test ID: PDHC
Pyruvate Dehydrogenase Complex (PDHC), Fibroblasts
Method Description 
Describes how the test is performed and provides a method-specific reference
Pyruvate dehydrogenase complex (PDHC) activity is determined by measuring the (14)CO(2), the end product of the E1 component of PDHC from (1-[14]C) pyruvate. In skin fibroblasts, 90% to 95% of PDHC activity is inactivated. The enzyme is activated by pretreating fibroblast cells with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase.(Sheu KF, Hu CW, Utter MF: Pyruvate dehydrogenase complex activity in normal and deficient fibroblasts. J Clin Invest 1981 May;67[5]:1463-1471)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Varies
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
60-70 days depending on rapidity of growth
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
70 day
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
3 years - Check with the lab for availability
Performing Laboratory Location The location of the laboratory that performs the test
Rochester
External
link
PDF
document
Excel
document
Word
document