Myasthenia Gravis (MG) Evaluation, Pediatric
Method Description Describes how the test is performed and provides a method-specific reference
Muscle acetylcholine receptor (AChR) binding (IgG and IgM) are measured quantitatively by immunoprecipitation assays. The high-affinity ligand (125)I-alpha-bungarotoxin is complexed with detergent-solubilized muscle AChR prepared from a mixture of innervated and denervated human muscle. AChR modulating antibodies is detected in a bioassay; (125)I-bungarotoxin measures percent loss of AChR from viable, noninnervated, monolayer cultures of human muscle cells following 14-hour incubation with patient's serum.(Griesmann GE, Kryzer TJ, Lennon VA: Autoantibody profiles of myasthenia gravis and Lambert-Eaton myasthenic syndrome. In Manual of Clinical and Laboratory Immunology. Sixth edition. Edited by NR Rose, RG Hamilton, B Detrick. Washington, DC, ASM Press, 2002, pp 1005-1012)
PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
ACh receptor (muscle) binding antibody: Monday through Friday, Sunday; 2 p.m.
ACh receptor (muscle) modulating antibodies: Monday through Thursday, Saturday; 12 p.m.