Multiple Sclerosis (MS) Profile
Method Description Describes how the test is performed and provides a method-specific reference
The oligoclonal banding (OCB) assay requires paired cerebrospinal fluid (CSF) and serum samples. Unconcentrated CSF and diluted serum are electrophoresed by isoelectric focusing. The separated IgG bands are visualized by an IgG immunoblot, and oligoclonal bands that are present in the CSF and not in the serum are reported. The assay uses reagents from Helena Laboratories.(Keir G, Luxton RW, Thompson EJ: Isoelectric focusing of cerebrospinal fluid immunoglobulin G: an annotated update. Ann Clin Biochem 1990 September;27:436-443)
The CSF IgG index also requires paired CSF and serum samples. The CSF and serum IgG and albumin are determined by immunonephelometry on a Siemens Nephelometer II. The CSF IgG index and synthesis rate are calculated and reported. In addition, the serum IgG and albumin, CSF IgG and albumin, and serum and CSF IgG/albumin ratios are reported.(Markowitz H, Kokmen E: Neurologic diseases and the cerebrospinal fluid immunoglobulin profile. Mayo Clin Proc 1983 April;58:273-274; Siemens Nephelometer II Operators Manual 1999)
PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Saturday; 7 a.m. - 12 p.m.