Test ID: FBALL
B-Cell Acute Lymphoblastic Leukemia (ALL), FISH
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
As an adjunct to conventional chromosome studies in patients with acute lymphoblastic leukemia (ALL), especially:
-When conventional chromosome studies do not demonstrate a classic chromosome anomaly
-For pediatric patients
-When results for conventional chromosome studies are normal or unavailable because of an unsuccessful study
Detecting clones with t(1;19), t(9;22), t(12;21), t(11;var), t(14;var), del(9p), +4, +10, or +17
Quantifying disease before and after treatment for patients with ALL
Assessing residual disease after treatment (in this situation, it is cost effective to order only those FISH probes that produced abnormal results prior to treatment)
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ADD1F | One Additional FISH Probe | No | No |
| ADD2F | Two Additional FISH Probes | No | No |
| ADD4F | Four Additional FISH Probes | No | No |
| ADD3F | Three Additional FISH Probes | No | No |
| ADD5F | Five Additional FISH Probes | No | No |
| ADD6F | Six Additional FISH Probes | No | No |
| ADD7F | Seven Additional FISH Probes | No | No |
| ADD8F | Eight Additional FISH Probes | No | No |
| ADD9F | Nine Additional FISH Probes | No | No |
| ADD10 | Ten Additional FISH Probes | No | No |
| ADD11 | Eleven Additional FISH Probes | No | No |
| ADD12 | Twelve Additional FISH Probes | No | No |
| 14FP | Fourteen Additional FISH Probes | No | No |
| 13FP | Thirteen Additional FISH Probes | No | No |
| 15FP | Fifteen Additional FISH Probes | No | No |
| 16FP | Sixteen Additional FISH Probes | No | No |
| 17FP | Seventeen Additional FISH Probes | No | No |
| 18FP | Eighteen Additional FISH Probes | No | No |
| 19FP | Nineteen Additional FISH Probes | No | No |
| 20FP | Twenty Additional FISH Probes | No | No |
| 21FP | Twenty One Additional FISH Probes | No | No |
| 22FP | Twenty Two Additional FISH Probes | No | No |
| 23FP | Twenty Three Additional FISH Probes | No | No |
| 24FP | Twenty Four Additional FISH Probes | No | No |
| 25FP | Twenty Five Additional FISH Probes | No | No |
| 26FP | Twenty Six Additional FISH Probes | No | No |
| 27FP | Twenty Seven Additional FISH Probes | No | No |
| 28FP | Twenty Eight Additional FISH Probes | No | No |
| 29FP | Twenty Nine Additional FISH Probes | No | No |
| 30FP | Thirty Additional FISH Probes | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
This panel includes testing for the following anomalies via the probes listed. The entire panel is recommended for pediatric patients.
t(9;22), BCR/ABL1
t(12;21), ETV6/RUNX1
t(1;19), PBX1/TCF3
+4, +10, +17, Cen4/Cen10/Cen17
t(11q23;var), MLL
del(9p), CDKN2A/Cen9
t(14;var), IGH
When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(4;11) AFF1/MLL and t(11;19)(q23;p13.1) MLL/ELL.
Pediatric patients: Please indicate if you would like the entire panel. This is suggested for pediatric patients with new diagnosis. If the patient is being tracked for known anomalies, please indicate which anomalies need to be investigated.
Adult patients: Only FISH for BCR/ABL1 and MLL are recommended in adult patients with B-cell ALL.
When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Fluorescence In Situ Hybridization (FISH) with DNA Probes
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
11q23 (MLL)
14q32 (IGH)
Acute Lymphoblastic Leukemia (ALL)
Adult Acute Lymphoblastic Leukemia (ALL)
CDKN2A/Cen9
del(9p) (p16)
Hyperdiploidy
p16
Pediatric Acute Lymphoblastic Leukemia (ALL)
t(1;19) (PBX1/TCF3)
t(12;21) (TEL/AML1)
t(9;22) (BCR/ABL)
TEL/AML1
ETV6/RUNX1
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