|Values are valid only on day of printing.|
Evaluating patients with chronic liver disease in whom the diagnosis of chronic active autoimmune hepatitis is suspected
Sera from patients with autoimmune chronic active hepatitis contain antibodies to smooth muscle antigens that are detectable by indirect immunofluorescence on substrates that contain smooth muscle. The antibodies are predominantly of the IgG isotype.
Other diseases in this differential diagnosis group include primary biliary cirrhosis, chronic viral hepatitis, and alcoholic chronic hepatitis.
If positive, results are titered.
Reference values apply to all ages.
Antibody titers in the range of 80 to 320 occur commonly in patients with active chronic hepatitis; lower titers (usually <80) may occur in the other conditions mentioned earlier.
No known false-positives or false-negatives
Czaja AJ, Homburger HA: Autoantibodies in liver disease. Gastroenterology 2001;120:239-249