Chronic Lymphocytic Leukemia (CLL), FISH
Method Description Describes how the test is performed and provides a method-specific reference
Identification of deletions on chromosomes 6q, 11q, 13q, and 17p, and trisomy of chromosome 12 are detected based on FISH enumeration strategy probes. A dual-color dual-fusion (D-FISH) strategy probe set is used to detect CCND1/IGH rearrangements and for reflex testing to identify BCL2/IGH and BCL3/IGH rearrangements. For the enumeration strategy probe sets 200 interphase nuclei are scored and 500 interphase nuclei are scored when D-FISH probes are used. Two technologists analyze each probe set and all results are expressed as percent abnormal nuclei.(Dewald GW, Brockman SR, Paternoster SF, et al: Chromosome anomalies detected by interphase FISH: correlation with significant biological features of B-cell chronic lymphocytic leukemia. Brit J Haematol 2003;121:287-295)
Supplemental Report Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Samples processed Monday through Sunday. Results reported Monday through Friday, 8 a.m.-5 p.m. CST.