Test ID: FAML
Acute Myeloid Leukemia (AML), FISH
NY State Approved 
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with acute myeloid leukemia or other myeloid malignancies
Evaluating specimens in which standard cytogenetic analysis is unsuccessful
Identifying and tracking known chromosome anomalies in patients with myeloid malignancies and tracking response to therapy
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ADD1F | One Additional FISH Probe | No | No |
| ADD2F | Two Additional FISH Probes | No | No |
| ADD4F | Four Additional FISH Probes | No | No |
| ADD3F | Three Additional FISH Probes | No | No |
| ADD5F | Five Additional FISH Probes | No | No |
| ADD6F | Six Additional FISH Probes | No | No |
| ADD7F | Seven Additional FISH Probes | No | No |
| ADD8F | Eight Additional FISH Probes | No | No |
| ADD9F | Nine Additional FISH Probes | No | No |
| ADD10 | Ten Additional FISH Probes | No | No |
| ADD11 | Eleven Additional FISH Probes | No | No |
| ADD12 | Twelve Additional FISH Probes | No | No |
| 14FP | Fourteen Additional FISH Probes | No | No |
| 13FP | Thirteen Additional FISH Probes | No | No |
| 15FP | Fifteen Additional FISH Probes | No | No |
| 16FP | Sixteen Additional FISH Probes | No | No |
| 17FP | Seventeen Additional FISH Probes | No | No |
| 18FP | Eighteen Additional FISH Probes | No | No |
| 19FP | Nineteen Additional FISH Probes | No | No |
| 20FP | Twenty Additional FISH Probes | No | No |
| 21FP | Twenty One Additional FISH Probes | No | No |
| 22FP | Twenty Two Additional FISH Probes | No | No |
| 23FP | Twenty Three Additional FISH Probes | No | No |
| 24FP | Twenty Four Additional FISH Probes | No | No |
| 25FP | Twenty Five Additional FISH Probes | No | No |
| 26FP | Twenty Six Additional FISH Probes | No | No |
| 27FP | Twenty Seven Additional FISH Probes | No | No |
| 28FP | Twenty Eight Additional FISH Probes | No | No |
| 29FP | Twenty Nine Additional FISH Probes | No | No |
| 30FP | Thirty Additional FISH Probes | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
See Acute Promyelocytic Leukemia: Guideline to Diagnosis and Follow-up in Special Instructions.
When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.
Please indicate if the entire panel is to be performed. This is suggested for patients with a new diagnosis of acute myeloid leukemia. If the patient is being treated for known anomalies, indicate which anomalies need to be investigated.
Indicate subtype as well as which anomalies need to be investigated from the following profile:
t(8:21), [M2], RUNX1T1/RUNX1
t(15:17), [M3], PML/RARA
t(11q23:var), [M0-M7], MLL
inv(16), [M4, Eos], MYH11/CBFB
+8, [M0-M7], Cen8/MYC
t(6;9), [M2,M4], DEK/NUP214
inv(3), [M1,2,4,6,7], RPN1/MECOM
t(8;16), [M4,M5], MYST3/CREBBP
t(1;22), [M7], RBM15/MKL1*
-5/5q-, D5S630/EGR1
-7/7q-, D7S486/Cen7
13q-, D13S319/LAMP1
17p-, TP53/Cen17
20q-, D20S108/20qter
t(9;22), BCR/ABL1
*The RBM15/MKL1 probe set will only be used to test patients with a suspected or confirmed diagnosis of M7 or to confirm a t(1;22) identified by chromosome analysis.
-When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(6;11)(q27;q23) MLLT4/MLL, t(9;11)(p22;q23) MLLT3/MLL, t(10;11)(p13;q23) MLLT10/MLL, t(11;16)(q23;p13.3) MLL/CREBBP, t(11;19)(q23;p13.1) MLL/ELL, or t(11;19)(q23;p13.3) MLL/MLLT1.
-When 3 copies of MECOM are observed with no fusion with RPN1 reflex testing using the MECOM/RUNX1 probe set is performed to identify a potential t(3;21)(q26.2;q22) rearrangement.
-When 3 copies of RPN1 are observed with no fusion with MECOM, reflex testing using the PRDM16/RPN1 probe set is performed to identify a potential t(1;3)(p36;q21).
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Fluorescence In Situ Hybridization (FISH)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
-7
11q23
5q-
7q-
Acute Myeloid Leukemia (AML)
Acute Promyelocytic Leukemia (APL)
AF6/MLL
AF9/MLL
AML-M2
AML-M3
AML-M4
AML-M4eo
AML-M5
APL (Acute Promyelocytic Leukemia)
DEK/CAN
Deletion 5q
Deletion 7q
ETO/AML1
EVI1/AML1
FISH (Fluorescence In Situ Hybridization)
Inv(16)
Inv(3)
inversion 16
inversion 3
MLL
MYH11/CBFb
NUP214
PML/RARA
t(15:17)
t(16:16)
t(3:21)
t(3;3)
t(6;9)
t(8:16)
t(8;21)
t(9;11)
RUNX1T1/RUNX1
MECOM/RUNX1
KAT6A/CREBBP
+8
13q-
17p-
20q-
AF10/MLL
AML-M0
AML-M1
AML-M7
BCR/ABL
BCR/ABL1
DEK/NUP214
Deletion 13q
Deletion 17p
Deletion 20q
ELL/MLL
ENL/MLL
idic(20)
isodicentric 20q
MLLT1/MLL
MLLT4/MLL
MLLT3/MLL
MLLT10/MLL
MLL/CREBBP
Monosomy 5
Monosomy 7
PRDM16/RPN1
RBM15/MKL1
t(1;3)
t(1;22)
t(6;11)
t(10;11)
t(11;16)
t(11;19)
TP53
Trisomy 8
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