Test ID: FMDS
Myelodysplastic Syndrome (MDS), FISH
NY State Approved 
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with myelodysplastic syndromes or other myeloid malignancies
Evaluating specimens in which standard cytogenetic analysis is unsuccessful
Identifying and tracking known chromosome anomalies in patients with myeloid malignancies and tracking response to therapy
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ADD1F | One Additional FISH Probe | No | No |
| ADD2F | Two Additional FISH Probes | No | No |
| ADD3F | Three Additional FISH Probes | No | No |
| ADD4F | Four Additional FISH Probes | No | No |
| ADD5F | Five Additional FISH Probes | No | No |
| ADD6F | Six Additional FISH Probes | No | No |
| ADD7F | Seven Additional FISH Probes | No | No |
| ADD8F | Eight Additional FISH Probes | No | No |
| ADD9F | Nine Additional FISH Probes | No | No |
| ADD10 | Ten Additional FISH Probes | No | No |
| ADD11 | Eleven Additional FISH Probes | No | No |
| ADD12 | Twelve Additional FISH Probes | No | No |
| 14FP | Fourteen Additional FISH Probes | No | No |
| 13FP | Thirteen Additional FISH Probes | No | No |
| 15FP | Fifteen Additional FISH Probes | No | No |
| 16FP | Sixteen Additional FISH Probes | No | No |
| 17FP | Seventeen Additional FISH Probes | No | No |
| 18FP | Eighteen Additional FISH Probes | No | No |
| 19FP | Nineteen Additional FISH Probes | No | No |
| 20FP | Twenty Additional FISH Probes | No | No |
| 21FP | Twenty One Additional FISH Probes | No | No |
| 22FP | Twenty Two Additional FISH Probes | No | No |
| 23FP | Twenty Three Additional FISH Probes | No | No |
| 24FP | Twenty Four Additional FISH Probes | No | No |
| 25FP | Twenty Five Additional FISH Probes | No | No |
| 26FP | Twenty Six Additional FISH Probes | No | No |
| 27FP | Twenty Seven Additional FISH Probes | No | No |
| 28FP | Twenty Eight Additional FISH Probes | No | No |
| 29FP | Twenty Nine Additional FISH Probes | No | No |
| 30FP | Thirty Additional FISH Probes | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
Chromosome analysis is recommended as first-tier testing for this disorder; FISH should be used if chromosomes are not successful.
When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.
Please indicate if the entire panel is to be performed. This is suggested for newly diagnosed patients. If the patient is being tracked for known anomalies, indicate which anomalies need to be investigated.
Panel includes testing for the following anomalies via the probes listed:
-5/5q-, D5S630/EGR1
-7/7q-, D7S486/Cen7
+8, Cen8/MYC
11q23 rearrangements, MLL
13q-, D13S319/LAMP1
17p-, TP53/cen17
20q-, D20S108/20qter
inv(3)/3q21 or 3q26.2 rearrangements, RPN1/MECOM
-When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(6;11)(q27;q23) MLTT4/MLL, t(9;11)(p22;q23) MLLT3/MLL, t(11;16)(q23;p13.3) MLL/CREBBP, t(11;19)(q23;p13.1) MLL/ELL, or t(11;19)(q23;p13.3) MLL/MLLT1.
-When 3 copies of MECOM are observed with no fusion with RPN1, reflex testing using the MECOM/RUNX1 probe set is performed to identify a potential t(3;21)(q26.2;q22) rearrangement.
-When 3 copies of RPN1 are observed with no fusion with MECOM, reflex testing using the PRDM16/RPN1 probe set is performed to identify a potential t(1;3)(p36;q21).
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Fluorescence In Situ Hybridization (FISH)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
-5
-7
11q23
13q-
20q-
5q-
7q-
AF6/MLL
AF9/MLL
Deletion 13q
Deletion 20q
Deletion 5q
Deletion 7q
FISH (Fluorescence In Situ Hybridization)
MDS (Myelodysplastic Syndrome)
MLL/ELL+8
Monosomy 5
Monosomy 7
t(11:19)
t(3:21)
t(3;3)
t(6:11)
t(9:11)
Trisomy 8
RPN1/EVI1
RPN1/MECOM
EVI1/AML1
Isodicentric 20q
MLL/ENL
MLL/MLLT1
MLLT4/MLL
MLLT3/MLL
PRDM16/RPN1
RPN1/AML1
t(1;3)
17p-
Deletion 17p
idic(20)
inv(3)
inversion 3
MECOM/RUNX1
MLL/CREBBP
Myeloproliferative neoplasms
Myelodysplastic Syndrome
MPN
t(11;16)
TP53
External
link
PDF
document
Excel
document
Word
document