Test ID: ACASM
Pernicious Anemia Cascade
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
83632
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Yes
Useful For Suggests clinical disorders or settings where the test may be helpful
Diagnosis of pernicious anemia
Diagnosis of vitamin B12 deficiency-associated neuropathy
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IFBPA | Intrinsic Factor Blocking Ab, S | Yes, (order IFBA) | No |
| MMAPA | Methylmalonic Acid, QN, S | Yes, (order MMAS) | No |
| GASTR | Gastrin, S | Yes, (order GAST) | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If vitamin B12 is <150 ng/L, then intrinsic factor blocking antibody (IFBA) is performed. If IFBA is negative or indeterminate, then gastrin is performed.
If vitamin B12 is 150 to 400 ng/L, then methylmalonic acid (MMA) is performed. If methylmalonic acid is >0.40 umol/L, then IFBA is performed.
See Pernicious Anemia Testing Cascade in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
B12PA/15153: Immunoenzymatic Assay
IFBPA/33050: Competitive-Binding Immunoenzymatic Assay
GASTR/33051: Automated Chemiluminescent Immunometric Assay
MMAPA/33049: Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS) Stable Isotope Dilution Analysis
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Pernicious Anemia Cascade
Aliases Lists additional common names for a test, as an aid in searching
B12 Assay
B12 Deficiency
Cobalamin
Cobalamin Deficiency
Cyanocobalamin
Gastrin
Intrinsic Factor Blocking Antibody
Islet Cell Tumor
Methylmalonate
Methylmalonic Acid (MMA)
MMA (Methylmalonic Acid)
Schilling Testing (Alternative Strategy)
Soft-ACASM
Type 1 Intrinsic Factor Antibody
Vitamin B 12
CblC
B12 Deficiency
Cobalamin
Cobalamin Deficiency
Cyanocobalamin
Gastrin
Intrinsic Factor Blocking Antibody
Islet Cell Tumor
Methylmalonate
Methylmalonic Acid (MMA)
MMA (Methylmalonic Acid)
Schilling Testing (Alternative Strategy)
Soft-ACASM
Type 1 Intrinsic Factor Antibody
Vitamin B 12
CblC
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