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Test ID: ACASM    
Pernicious Anemia Cascade

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Secondary ID A test code used for billing and in test definitions created prior to November 2011

83632

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis of pernicious anemia

 

Diagnosis of vitamin B12 deficiency-associated neuropathy

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
IFBPAIntrinsic Factor Blocking Ab, SYes, (order IFBA)No
MMAPAMethylmalonic Acid, QN, SYes, (order MMAS)No
GASTRGastrin, SYes, (order GAST)No

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If vitamin B12 is <150 ng/L, then intrinsic factor blocking antibody (IFBA) is performed. If IFBA is negative or indeterminate, then gastrin is performed.

If vitamin B12 is 150 to 400 ng/L, then methylmalonic acid (MMA) is performed. If MMA is >0.40 nmol/mL, then IFBA is performed.

 

See Pernicious Anemia Testing Cascade in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Immunoenzymatic Assay

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Pernicious Anemia Cascade

Aliases Lists additional common names for a test, as an aid in searching

B12 Assay
B12 Deficiency
Cobalamin
Cobalamin Deficiency
Cyanocobalamin
Gastrin
Intrinsic Factor Blocking Antibody
Islet Cell Tumor
Methylmalonate
Methylmalonic Acid (MMA)
MMA (Methylmalonic Acid)
Schilling Testing (Alternative Strategy)
Soft-ACASM
Type 1 Intrinsic Factor Antibody
Vitamin B 12
CblC