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Test ID: PAVAL    
Paraneoplastic Autoantibody Evaluation, Serum

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Secondary ID A test code used for billing and in test definitions created prior to November 2011

83380

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer

 

Directing a focused search for cancer

 

Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis

 

Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy

 

Monitoring the immune response of seropositive patients in the course of cancer therapy

 

Detecting early evidence of cancer recurrence in previously seropositive patients

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
PAINTInterpretive CommentsNoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2SAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3SAnti-Neuronal Nuclear Ab, Type 3NoYes
AGN1SAnti-Glial Nuclear Ab, Type 1NoYes
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoYes
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoYes
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoYes
AMPHSAmphiphysin Ab, SNoYes
CRMSCRMP-5-IgG, SNoYes
STRStriational (Striated Muscle) Ab, SYesYes
CCPQP/Q-Type Calcium Channel AbNoYes
CCNN-Type Calcium Channel AbNoYes
ARBIACh Receptor (Muscle) Binding AbYesYes
GANGAChR Ganglionic Neuronal Ab, SNoYes
VGKCNeuronal (V-G) K+ Channel Ab, SNoYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
GD65SGAD65 Ab Assay, SYesNo
WBNParaneoplastic Autoantibody WBlot,SNoNo
CRMWSCRMP-5-IgG Western Blot, SNoNo
ARMOACh Receptor (Muscle) Modulating AbNoNo
ABLOTAmphiphysin Western Blot, SNoNo
NMOCSNMO/AQP4-IgG CBA, SYesNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If IFA (ANN1S, ANN2S, ANN3S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AGN1S) patterns are indeterminate, paraneoplastic autoantibody Western blot is performed at an additional charge.

If client requests or if IFA patterns suggest CRMP-5-IgG, CRMP-5-IgG Western blot is performed at an additional charge.

If IFA pattern suggest NMO/AQP4-IgG, NMO/AQP4-IgG CBA is performed at an additional charge.

If IFA patterns suggest amphiphysin antibody, amphiphysin Western blot is performed at an additional charge.

If IFA patterns suggest GAD65 antibody, GAD65 antibody radioimmunoassay is performed at an additional charge.

If ACh receptor binding antibody is >0.02 or if striational antibodies are > or =1:60, ACh receptor modulating antibodies and CRMP-5-IgG Western blot are performed at an additional charge.

 

CRMP-5-IgG Western blot is also performed by specific request for more sensitive detection of CRMP-5-IgG. Testing should be requested in cases of subacute basal ganglionic disorders (chorea, Parkinsonism), cranial neuropathies (especially loss of vision, taste, or smell) and myelopathies.

 

See Paraneoplastic Evaluation Algorithm in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

ANN1S, ANN2S, ANN3S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AGN1S: Indirect Immunofluorescence Assay (IFA)

STR: Enzyme Immunoassay (EIA)

CCPQ, CCN, ARBI, ARMO, GANG, VGKC: Radioimmunoassay (RIA)

WBN, CRMWS, ABLOT: Western Blot

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Paraneoplastic Autoantibody Eval, S

Aliases Lists additional common names for a test, as an aid in searching

Acetylcholine Receptor (Muscle AChR) Antibodies
AChR (Acetylcholine Receptor)
AGNA
Amphiphysin Antibody, Serum
ANNA (Antineuronal Nuclear Antibody)
Anti-CV2
Anti-Enteric Neuronal Antibody
Anti-GAD65 (Anti-Glutamic Acid Decarboxylase)
Anti-Glial Nuclear Antibody
Anti-Hu
Anti-Purkinje Cell Cytoplasmic Antibodies
Anti-Ri
Anti-Skeletal Muscle Antibodies
Anti-Yo
Antineuronal
APCA (Anti-Purkinje Cell Antibodies)
Calcium Channel Blockers
Cerebellar Antibodies
Chorea
Cramp-fasciculation
CRMP-5, IgG
Dorsal Root Ganglion Antibody
Glutamate Decarboxylase Antibodies (GAD65)
Hu Antibody
Motor End-Plate Antibody
Motor Nerve Terminal Antibodies
Muscle (Skeletal) Antibodies
Muscle Culture Antibodies
Myoid Antibody
N-Type Calcium Channel Antibody
Neuromyotonia
Neuronal Nuclear Antibody
Neuronal Nuclear Antibody Panel
Neuronal Potassium Channel Ab
Neuronal-Anti
Ovarian Cancer-Related Antibodies
P/Q Type Calcium Channel Antibody
Paraneoplastic Antibodies
Paraneoplastic Autoantibody Evaluation
Paraneoplastic Neurological Autoimmunity
PCA-1 (Purkinje Cell Cytoplasmic Antibodies)
PCA-2 (Purkinje Cell Cytoplasmic Antibodies)
PCA-Tr (Purkinje Cell Cytoplasmic Antibodies)
PCAb (Purkinje Cell Cytoplasmic Antibodies)
Potassium Channel Antibodies (specify)
Purkinje Cell Cytoplasmic Antibodies, Type 1
Purkinje Cell Cytoplasmic Antibodies, Type 2
Purkinje Cell Cytoplasmic Antibodies, Type Tr
Ri, Anti
Stiff-man Syndrome
Striational (Striated Muscle) Antibodies
VGCC (Voltage-Gated Calcium Channel) Antibodies
VGKC
VGPC
Voltage-Gated Potassium Channel Ab
Yo-Anti
Neuronal Ganglionic Acetylcholine Receptor Antibody
Cantoxin Receptor Antibodies
Collapsin Response-Mediator Protein-5 Antibody (CRMP-5)
Isaacs Disease
Neuromuscular Hyperexcitability
Purkinje Cell Cytoplasmic Antibodies