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Test ID: FPCPD    
Plasma Cell Proliferative Disorder (PCPD), FISH

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Secondary ID A test code used for billing and in test definitions created prior to November 2011

83358

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

Aiding in the diagnosis of new cases of multiple myeloma or other plasma cell proliferative disorders

 

Identifying prognostic markers based on the anomalies found

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

This test is designed for diagnostic specimens. The test panel includes analysis for the disease-associated abnormalities using the probes listed below:

 

-13/13q-, RB1/LAMP1

t(11;14), CCND1/IGH

t(14;var), IGH

17p-, TP53/Cen17

+3/+7, Cen3/Cen7

+9/+15, Cen9/Cen15

1q gain, TP73/CKS1B

t(8;var), MYC

 

When an IGH rearrangement is identified and the partner is not CCND1, reflex testing is performed to identify the translocation partner. Probes include identification of t(4;14)(p16.3;q32) FGFR3/IGH, t(14;16)(q32;q23) IGH/MAF, t(14;20)(q32;q12) IGH/MAFB, or t(6;14)(p21;q32) CCND3/IGH.

 

Initial screening will be performed using a limited number of probes to determine if sufficient plasma cells are present within the provided specimen.

 

For diagnostic samples (unless otherwise specified), all probes in the panel will be evaluated if sufficient plasma cells are identified.

 

For follow-up samples (unless otherwise specified), only TP73/CKS1B, TP53/Cen17 and MYC probes along with probes that were abnormal in a previous study will be tested. If a previous sample was uninformative due to an insufficient number of plasma cells, the complete panel will be evaluated (if sufficient plasma cells are identified).

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Cytoplasmic Immunoglobulin (cIg) Staining Followed by Fluorescence In Situ Hybridization (FISH)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Plasma Cell Prolif Disorder, FISH

Aliases Lists additional common names for a test, as an aid in searching

Deletion 13
Deletion 17p
Monoclonal Gammopathy of Unknown Significance (MGUS)
Monosomy 13
Multiple Myeloma
Plasma Cell Leukemia
RB1
TP53
+1q
CKS1B
MYC
t(11;14) - CCND1/IGH
t(14;16) - IGH/c-MAF
t(14;20) - IGH/MAFB
t(4;14) - FGFR3/IGH
t(6;14) - CCND3/IGH