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Test ID: BDIAL    
Bleeding Diathesis Profile, Limited

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Secondary ID A test code used for billing and in test definitions created prior to November 2011

83094

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Useful For Suggests clinical disorders or settings where the test may be helpful

Detection of the more common potential causes of abnormal bleeding (eg, factor deficiencies/hemophilia, von Willebrand disease, factor-specific inhibitors) and a simple screen to evaluate for an inhibitor or severe deficiency of factor XIII (rare).

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
PTCProthrombin Time (PT), PYes, (order PT)Yes
APTTBActivated Partial Thrombopl Time, PYes, (order APT)Yes
TTThrombin Time (Bovine), PYesYes
DIRMD-Dimer, PYes, (order DDI)Yes
SFMSoluble Fibrin MonomerNoYes
FIBCFibrinogen, PYes, (order FIB)Yes
F8ACoag Factor VIII Activity Assay, PYesYes
VWAGvon Willebrand Factor Ag, PYesYes
VWFXvon Willebrand Factor Activity, PYesYes
FXIIIFactor XIII(13),ScrnNoYes
CCCSpecial Coagulation InterpretationNoYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
IBETHBethesda UnitsNoNo
F8ISCoag Factor VIII Assay Inhib Scrn,PNoNo
RISTRistocetin Cofactor, PNoNo
FACTVCoag Factor V Assay, PYesNo
F_7Coag Factor VII Assay, PYesNo
F_9Coag Factor IX Assay, PYesNo
F_10Coag Factor X Assay, PYesNo
F_11Coag Factor XI Assay, PYesNo
F_12Coag Factor XII Assay, PYesNo
RPTLReptilase Time, PYesNo
APSMAlpha-2 Plasmin Inhibitor, PYesNo
F_2Coag Factor II Assay, PYesNo
DRVTDilute Russells Viper Venom Time, PNoNo
F9_ISFactor IX Inhib ScrnNoNo
11_ISFactor XI Inhib ScrnNoNo
F2_ISFactor II Inhib ScrnNoNo
F5_ISFactor V Inhib ScrnNoNo
F7_ISFactor VII Inhib ScrnNoNo
10_ISFactor X Inhib ScrnNoNo
PNPPlatelet Neutralization ProcedureNoNo
PTMXPT Mix 1:1NoNo
APTTMAPTT Mix 1:1NoNo
DRVTMDRVVT MixNoNo
DRVTCDRVVT ConfirmationNoNo
STLAStaclot LA, PNoNo
VWFMvon Willebrand Factor Multimer, PYes, (order 8844)No

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

Initial testing includes: prothrombin time (PT), activated partial thromboplastin time, thrombin time (bovine), fibrinogen, D-dimer, soluble fibrin monomer, coagulation factor VIII activity assay, von Willebrand factor antigen, von Willebrand factor activity, factor XIII screen, and special coagulation interpretation.  

If PT is > or =14 seconds, PT mix will be performed.

If APTT is >36 seconds, APTT mix and DRVVT will be performed.

If DRVVT ratio is > or =1.2, DRVVT mix will be performed.

If DRVVT mix ratio is > or =1.2, DRVVT confirmation will be performed

If APTT mix is >36 seconds with no evidence of heparin in samples, platelet neutralization procedure will be performed.

If thrombin time is >23 seconds, reptilase time will be performed.

If von Willebrand factor activity assay is <55%, von Willebrand factor ristocetin cofactor activity assay will be performed.  

If von Willebrand factor (VWF) antigen is <55%, the VWF activity is <55%, or the VWF activity:VWF antigen ratio is <0.8, VWF multimer analysis will be performed.

If appropriate, coagulation factor assays or Staclot LA will be performed at an additional charge to clarify significant abnormalities in the screening clotting times.

If factor VIII result is <55%, the factor VIII inhibitor screen may be performed along with the Bethesda titering assay, if inhibitor screen is positive.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

PTC, PTMX, APTTB, APTTM, TT, FXIII, DRVT, DRVTM, DRVTC, STLA: Clot-Based Assay

F2_IS, F5_IS, F7_IS, 10_IS: Prothrombin Time Clot-Based Assay

F8A, F9_IS, 11_IS: Activated Partial Thromboplastin Time-Based Clotting Assay

PNP: Activated Partial Thromboplastin Time (APTT) Mixing Test

RIST: Ristocetin Induced Agglutination of Washed Normal Platelets

VWAG, DIRM/6625: Automated Latex Immunoassay (LIA)

SFM: Immunoturbidimetric

FIBC: Clauss Methodology

VWFX: Latex Particle Enhanced Immunoassay

IBETH, F8IS: Clot-Based Assay

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Bleeding Diath Prof, Limited

Aliases Lists additional common names for a test, as an aid in searching

Bleeding Diathesis Profile, Limited
Coag