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Test ID: PNEOE    
Paraneoplastic Autoantibody Evaluation, Spinal Fluid

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Secondary ID A test code used for billing and in test definitions created prior to November 2011


NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

An aid in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin's lymphoma


In patients with a history of tobacco use or other lung cancer risk, or if thymoma is suspected, PAVAL / Paraneoplastic Autoantibody Evaluation, Serum is also recommended.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
ANN1CAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2CAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3CAnti-Neuronal Nuclear Ab, Type 3NoYes
AGN1CAnti-Glial Nuclear Ab, Type 1NoYes
PCA1CPurkinje Cell Cytoplasmic Ab Type 1NoYes
PCA2CPurkinje Cell Cytoplasmic Ab Type 2NoYes
PCTRCPurkinje Cell Cytoplasmc Ab Type TrNoYes
AMPHCAmphiphysin Ab, CSFNoYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
WBNCParaneoplas Autoantibody WBlot,CSFNoNo
CRMWCCRMP-5-IgG Western Blot, CSFNoNo
GD65CGAD65 Ab Assay, CSFYesNo
ABLTCAmphiphysin Western Blot, CSFNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AGN1C) is indeterminate, paraneoplastic autoantibody Western blot is performed at an additional charge.

If IFA pattern suggest NMO/AQP4-IgG, NMO/AQP4-IgG CBA is performed at an additional charge.

If client requests or if IFA patterns suggest CRMP-5-IgG, CRMP-5-IgG Western blot is performed at an additional charge.

If IFA patterns suggest GAD65 antibody, GAD65 antibody radioimmunoprecipitation assay is performed at an additional charge.

If IFA patterns suggest amphiphysin antibody, amphiphysin Western blot is performed at an additional charge.

Method Name A short description of the method used to perform the test

ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AGN1C, NMOC: Indirect Immunofluorescence Assay (IFA)

WBNC, CRMWC, ABLTC: Western Blot

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Paraneoplas Autoantibody Eval,CSF

Aliases Lists additional common names for a test, as an aid in searching

Cerebellar Antibodies
Dorsal Root Ganglion Antibody
Hu Antibody
Neuron Restricted Autoantibodies
Neuronal Nuclear Antibody
Ovarian Cancer-Related Antibodies
Paraneoplastic Autoantibody Western Blot Confirmation, CSF
Paraneoplastic Neurological Autoimmunity
Purkinje Cell Cytoplasmic Antibodies
Ri, Anti
Amphiphysin Ab, CSF (order PNEOE)
ANNA-1, CSF (order PNEOE)
ANNA-2, CSF (order PNEOE)
ANNA-3, CSF (order PNEOE)
CRMP-5-IgG, CSF (order PNEOE)
PCA-1, CSF (order PNEOE)
PCA-2, CSF (order PNEOE)
PCA-Tr, CSF (order PNEOE)