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Test Catalog

Test ID: PEWE    
Porphyrins Evaluation, Washed Erythrocytes

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NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis of erythropoietic protoporphyria and congenital erythropoietic porphyria


Evaluation of chronic intoxication from exposure to a variety of agents including heavy metals and chemicals


Differentiating iron-deficiency anemia from other causes of elevated porphyrin levels

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
PPFRProtoporphyrins, FractionationYes, (order PPFE)No

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

Testing begins with total RBC porphyrins. If the result is <80 mcg/dL, it is normal and testing is complete. If the total RBC porphyrin value is >80 mcg/dL, fractionation assays will be performed at an additional charge to identify the porphyrin involved. The protoporphyrin fractionation yields free protoporphyrin and zinc-complexed protoporphyrin. Depending on this result, porphyrins fractionation may be added, which fractionates and individually quantitates RBC porphyrins (uroporphyrin, coproporphyrin, and protoporphyrin).


The following algorithms are available in Special Instructions:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

PEWE: Spectrofluorometric

PPFR: High-Performance Liquid Chromatography (HPLC)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Porphyrin Evaluation, RBC

Aliases Lists additional common names for a test, as an aid in searching

Congential Erythropoietic Porphryia (CEP)
Erythrocyte Porphyrin
Erythropoietic Protoporphyria (EPP)
Free Erythrocyte Porphyrin (FEP)
Heptacarboxyl Porphyrin
Pentacarboxyl Porphyrin
Protoporphyrins, Total, Erythrocytes
Red Blood Cell (RBC) Porphyrins
Hexacarboxyl Porphyrin