Test ID: PEWE
Porphyrins Evaluation, Washed Erythrocytes
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Diagnosis of erythropoietic protoporphyria and congenital erythropoietic porphyria
Evaluation of chronic intoxication from exposure to a variety of agents including heavy metals and chemicals
Differentiating iron-deficiency anemia from other causes of elevated porphyrin levels
There are 2 test options: PEE/88886 Porphyrins Evaluation, Whole Blood and PEWE/31893 Porphyrins Evaluation, Washed Erythrocytes. The whole blood option is easiest for clients but requires that the specimen arrive at Mayo Medical Laboratories within 48 hours of draw. When this cannot be ensured, washed RBCs should be submitted.
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| PFR | Porphyrins, Fractionation | No | No |
| PPFR | Protoporphyrins, Fractionation | Yes, (order PPFE) | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
Testing begins with total RBC porphyrins. If the result is <80 mcg/dL, it is normal and testing is complete. If the total RBC porphyrin value is >80 mcg/dL, fractionation assays will be performed at an additional charge to identify the porphyrin involved. The PPFR/28116 Protoporphyrin, Fractionation, Reflex fractionates RBC protoporphyrin into free protoporphyrin and zinc-complexed protoporphyrin. Depending on this result, the PFR/28117 Porphyrins, Fractionation, Reflex may be added which fractionates and individually quantitates RBC porphyrins (uroporphyrin, coproporphyrin, and protoporphyrin).
The following algorithms are available in Special Instructions:
-Porphyria (Acute) Testing Algorithm
-Porphyria (Cutaneous) Testing Algorithm
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
PEWE/31893: Spectrofluorometric
PPFR/28116, PFR/28117: High-Performance Liquid Chromatography (HPLC)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Coproporphyrin
Erythrocyte Porphyrin
Erythropoietic Protoporphyria (EPP)
Free Erythrocyte Porphyrin (FEP)
Heptacarboxyl Porphyrin
Pentacarboxyl Porphyrin
Protoporphyrin
Protoporphyrins, Total, Erythrocytes
Red Blood Cell (RBC) Porphyrins
Uroporphyrin
Hexacarboxyl Porphyrin
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