Assessing erythropoietic bone marrow activity in anemia and other hematologic conditions
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Reticulocytes are immature erythrocytes (RBC) that have been released into the peripheral blood from the bone marrow after extrusion of their nucleus. The reticulocyte contains residual polyribosomes used in the formation of hemoglobin in the developing erythrocyte.
The reticulocyte count is a measure of the number of RBCs delivered by the bone marrow. It is elevated with active erythropoiesis such as regeneration, and is decreased in hypoplastic or deficiency conditions such as vitamin B12 deficiency.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
% Reticulocytes: 0.77-2.36%
Absolute reticulocytes: 38.1-112.6 x 10(9)/L
Reticulocyte counts must be carefully correlated with other clinical and laboratory findings.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Clotted specimens yield unreliable results and are unacceptable for analysis.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Clinical Hematology: Principles, procedures, correlations. Second edition. Edited by CA Lotspeich-Steininger, EA Stiene-Martin, JA Koepke. Philadelphia, Lippincott-Raven, 1998, pp 114-117