Antibody Identification, Erythrocytes
Assessing positive pretransfusion antibody screens, transfusion reactions, hemolytic disease of the newborn, and autoimmune hemolytic anemias
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
After exposure to foreign red blood cells via transfusion or pregnancy, some people form antibodies which are capable of the destruction of transfused red cells or of fetal red cells in utero. It is important to identify the antibody specificity in order to assess the antibody's capability of causing clinical harm and, if necessary, to avoid the antigen on transfused red blood cells.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
If positive, antibodies will be identified and corresponding special red cell antigen typing on patient's red blood cells will be performed. A consultation service is offered, at no charge, regarding the clinical relevance of red cell antibodies.
Specificity of alloantibodies will be stated.
The patient's red blood cells will be typed for absence of the corresponding antigen(s) or as an aid to identification in complex cases.
A consultation service is offered, at no charge, regarding the clinical relevance of red cell antibodies.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Recent administration of Rh-immune globulin may cause anti-D to be identified and appear falsely as an alloantibody
Not useful for monitoring the efficacy of Rh-immune globulin administration
Not useful for identifying antibodies detected only at 4 degrees C or only after extended room temperature incubation
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Technical Manual. Bethesda, MD, American Association of Blood Banks