Chromosome Analyses for Neoplastic Disorders
- 8506 Chromosome Analysis, For Hematologic Disorders,
Bone Marrow
- 8537 Chromosome Analysis, For Hematologic Disorders,
Blood
- 8911 Chromosome Analysis, Lymph Node
- 8912 Chromosomes, Body Fluid
- 80258 Chromosomes, Solid Tumor
FISH
studies for Neoplastic Disorders
- The
following FISH tests/panels are also listed below
by corresponding disorder.
- 88897
B-Cell Lymphoma, FISH, Blood or Bone Marrow
- 80027
B-Cell Lymphoma, FISH, Tissue
- 80578 BCR/ABL,
Translocation 9;22, FISH (D-FISH)
- 80601
XX/XY in Opposite Sex Bone Marrow Transplantation,
FISH
- 80602
Chromosome Anomalies, Unspecified Miscellaneous with Chromosome-Specific FISH Probes
- 81616 B-Cell Acute Lymphoblastic Leukemia (ALL), FISH
- 81954 HER-2/neu Amplification Associated with Breast Cancer, FISH
- 83089 Chronic Lymphocytic Leukemia (CLL), FISH
- 83358
Plasma Cell Proliferative Disorder (PCPD),
FISH
- 84308 CHIC2 Anomalies at 4q12, FISH
- 84387 Myelodysplastic Syndrome (MDS), FISH
- 84463 PDGFRB/TEL Translocation
(5;12) for Chronic Myelomonocytic Leukemia,
FISH
- 87894 Acute Myeloid Leukemia (AML), FISH
- 88783 T-Cell Acute Lymphoblastic Leukemia (T-ALL), FISH
- 89040 T-Cell Lymphoma, FISH, Blood or Bone Marrow
Acute
Lymphoblastic Leukemia (ALL) - B-Cell
- 81616 B-Cell Acute Lymphoblastic Leukemia (ALL), FISH
- Panel,
recommended for pediatric patients, includes testing
for the following anomalies via the probes listed:
- t(9;22),
BCR/ABL
- t(12;21), TEL/AML1
- t(1;19), PBX1/TCF3
- +4,
+10, +17, Cen4/10/17
- t(11q23;var), MLL
- del
(9p), P16/Cen9
- Pediatric
patients: Please indicate if you would like the
entire panel. This is suggested for pediatric
patients with a new diagnosis. If patient is
being tracked for known anomalies, please indicate
which anomalies need to be investigated.
- Adult
patients: Only FISH for BCR/ABL and MLL are recommended in adult patients with B-Cell ALL.
Acute
Lymphoblastic Leukemia (ALL) – T-Cell
- 88783
T-Cell Acute Lymphoblastic Leukemia (T-ALL), FISH
- Please
indicate that the patient has pre-T cell ALL.
- ABL/CAN co-amplification, ABL/CAN/cen 9
- del(9)(p21), p16/cen 9
- t(11;var)(q23;var), MLL
Acute
Myeloid Leukemia (AML)
- 87894
Acute Myeloid Leukemia (AML), FISH
- Please
indicate subtype as well as which anomalies need
to be investigated, from the following profile:
- t(8;21),
[M2], ETO/AML1
- t(15;17),
[M3], PML/RARA
- t(11q23;var),
[M0-M7], MLL
- inv(16),
[M4, Eos], MYH11/CBFbeta
- +8,
[M0-M7], Cen8/c-MYC
- t(6;9),
[M2, M4], DEK/CAN
- inv(3),
[M1,2,4,6,7], RPN1/EVI1
Chronic
Lymphocytic Leukemia (CLL)
- 83089
Chronic Lymphocytic Leukemia (CLL), FISH
-
FISH panel is recommended in place of chromosome
analysis for this disorder. Panel includes testing
for the following anomalies via the probes listed:
- 6q-,
c-MYB/Cen6
- 11q-, ATM/Cen11
- +12,
D12Z3/MDM2
- 13q-,
D13S319/LAMP1
- 17p-, p53/Cen17
- t(11;14), CCND1/
IgH
- reflex
for IgH anomaly:
- t(14;18), IgH
/BCL2
- t(14;19), IgH
/BCL3
Chronic
Myeloid Leukemia (CML)
- 80578 BCR/ABL,
Translocation 9;22, FISH
Chronic
Myelomonocytic Leukemia (CMML)
- 84463 PDGFRB/TEL, Translocation
(5;12) for Chronic Myelomonocytic Leukemia,
FISH
Hypereosinophilic
Syndrome
- 84308 CHIC2 Anomalies at 4q12 Deletion, FISH
Imatinib Mesylate Responsive Genes
- 87995 Imatinib Mesylate Responsive Genes, FISH
- Panel,
recommended for pediatric patients, includes testing
for the following anomalies via the probes listed:
- 1q25 anomalies, ARG
- 4q12 anomalies, PDGFRA
- 5q33 anomalies, PDGFRB
- 9q34 anomalies, ABL
- 88897 B-Cell Lymphoma, FISH, Blood or Bone Marrow
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(8;14), c-MYC/IGH
- t(8q24.1;var), c-MYC
- t(11;14), CCND1/IGH
- t(11;18), API2/MALT1
- t(14;18), IGH/MALT1
- t(14;18), IGH/BCL2
- t(3;var), BCL6
- 80027
B-Cell Lymphoma, FISH, Tissue
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(11;14),
CCND1/ IGH
- t(14;18), IGH
/BCL2
- t(8q24.1;var), c-MYC
- t(8;14), c-MYC/
IGH
- t(11;18)
, API2/MALT1
- reflex t(14;18), IGH /MALT1
- Cen3/Cen7
- Cen12/Cen18
- t(3q27;var), BCL6
- 89040 T-Cell Lymphoma, FISH, Blood or Bone Marrow
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(14;var)(q32.1;var), TCL1
- -7/7q-/i(7q), D7S486/cen7
- +8, cen8/c-MYC
- 89041 T-Cell Lymphoma, FISH, Tissue
- Includes
a mini-pathology consult to evaluate appropriate
FISH probes and translocations to investigate.
Panel includes testing for the following anomalies
via the probes listed:
- t(14;var)(q32.1;var), TCL1
- -7/7q-/i(7q), D7S486/cen7
- +8, cen8/ c-MYC
- t(2;var)(p23.2;var)/inv(2) ALK
- ABL/CAN co-amplication ABL/CAN/cen9
- del(9)(p21) p16/cen9
- t(11;var)(q23;var) MLL
Myelodysplastic
Syndrome (MDS)
- 84387
MDS, Locus Anomalies, FISH
- Chromosome
analysis is recommended as first tier testing
for this disorder; FISH should be used if chromosomes
are not successful.
- Panel
includes testing for the following anomalies via
the probes listed:
- -5/5q-,/EGR1/D5S630
- -7/7q-,
D7S486/Cen7
- +8,
Cen8/c-MYC
- 13q-,
D13S319/ LAMP1
- 20q-, 20qter/D20S108
- inv(3), RPN1/EVI1
- Please
indicate if you would like us to run the entire
panel. This is suggested for patients with a
new diagnosis. If patient is being tracked for
known anomalies, please indicate which anomalies
need to be investigated.
Plasma
Cell Proliferative Disorder (PCPD)
- 83358
Plasma Cell Proliferative Disorder (PCPD),
FISH
- Testing
for Multiple Myeloma, intended for diagnosis only.
Fresh bone marrow specimen is required.
- Panel
includes testing for the following anomalies via
the probes listed:
- -13/13q-,
Rb1/LAMP1
- t(11;14), CCND1/ IGH
- t(14;var), IGH
- 17p-, p53/Cen17
- +3/+7,
Cen3/Cen7
- +9/+15,
Cen9/Cen15
- t(4;14) IGH
reflex, FGFR3/ IGH
- t(14;16) IGH
reflex, IGH /c-MAF
- 80258
Chromosome Analysis, Solid Tumors
- 81954
HER-2/neu Amplification Associated with Breast Cancer, FISH
Inflammatory Myofibroblastic tumors
- 89067 Inflammatory Myofibroblastic Tumors (IMT), FISH, Tissue
- 87862 N-myc Amplification, FISH
- 80029
1p/19q Deletion in Gliomas, FISH
- 83656
Ewing Sarcoma (EWS) Anomalies at 22q12, FISH
- Requires
paraffin embedded specimen. Referred for RT-PCR
first and then reflexed to FISH if warranted.
- 84456
Myxoid/Round Cell Liposarcoma 12q13 (CHOP) Rearrangement, FISH, Paraffin-Embedded Tissue
- 86177
Synovial Sarcoma (SS) Anomalies at 18q11.2 (SYT) Rearrangement,
FISH
- Requires
paraffin embedded specimen. Referred for RT-PCR
first and then reflexed to FISH if warranted.
86375
Alveolar Rhabdomyosarcoma (ARMS) 13q14 (FKHR) Rearrangement, FISH, Tissue
