Immunoglobulin D (IgD), Serum
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Quantitative determination of the immunoglobulins can provide important information on the humoral immune status.
Changes in IgD concentration are used as a marker of changes in the size of the clone of monoclonal IgD plasma cells.
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Immunoglobulin D (IgD), S
IgD (Immunoglobulin D)
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 1 mL
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Mild OK; Gross OK
Mild OK; Gross reject
Mild OK; Gross OK
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
|Serum||Refrigerated (preferred)||21 days|
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Antibodies or immunoglobulins (Ig) are formed by plasma cells as a humoral immune response to antigens. The first antibodies formed after antigen stimulation are of the IgM class, followed later by IgG and also IgA antibodies. IgD normally occurs in serum in trace amounts.
Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic diseases (chronic hepatitis, liver cirrhosis), acute and chronic infections, autoimmune diseases, as well as in the cord blood of neonates with intrauterine and perinatal infections. Increases in serum immunoglobulin concentration are seen in monoclonal gammopathies such as multiple myeloma, Waldenstrom's macroglobulinemia, primary amyloidosis, and monoclonal gammopathy of undetermined significance.
Decreased serum immunoglobulin concentrations occur in primary immunodeficiency conditions as well as in secondary immune insufficiencies including advanced monoclonal gammopathies, lymphatic leukemia, and advanced malignant tumors.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
< or =10 mg/dL
The physiologic significance of serum IgD concentration is unclear and in many normal persons serum IgD is undetectable.
Increased concentrations may be due to polyclonal (reactive) or monoclonal plasma cell proliferative processes.
A monoclonal IgD protein is present in 1% of patients with myeloma. Monoclonal IgD proteins are often in low concentrations and do not have a quantifiable M-peak on serum protein electrophoresis. However, the presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
An elevated IgD cannot be taken as evidence for a monoclonal IgD protein. MPSS/81756 Monoclonal Protein Studies, Serum should be performed to distinguish between a polyclonal and monoclonal IgD.
An elevated IgD cannot be taken as evidence for a monoclonal IgD protein. Immunofixation should be performed to distinguish between a polyclonal and monoclonal IgD.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Blade J, Kyle RA: Immunoglobulin D multiple myeloma: Presenting features, response to therapy, and survival in a series of 53 cases. J Clin Oncol 1994;12(11):2398-2404
2. Kyle RA, Katzmann JA: Immunochemical characterization of immunoglobulins. In Manual of Clinical Laboratory Immunology. 5th edition. Edited by NR Rose, E Conway de Macario, JD Folds, et al: Washington, DC, ASM Press,1997, pp 156-176
3. Tietz NW: In Clinical Guide to Laboratory Tests. 2nd edition. Philadelphia, WB Saunders Company, 1990, p 325
Method Description Describes how the test is performed and provides a method-specific reference
Nephelometry and anti-IgD antiserum. (Siemens Nephelometer II Operator's Manual 2005. Siemens, Newark, DE)
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Saturday; Continuously until 3 p.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Same day/1 day
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
|Result ID||Reporting Name||LOINC Code|
|IGD||Immunoglobulin D (IgD), S||2460-4|