Test ID: FNEU
Neurotransmitter Metabolites/Amines
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Method Name A short description of the method used to perform the test
HPLC-Electrochemistry
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Medical Neurogenetics collection kit (MML Supply T657) required.
Each collection kit contains 5 microcentrifuge tubes.
COLLECTION PROTOCOL
1) CSF should be collected from the first drop into the tubes in
the numbered order. Fill each tube to the marked line with
the required volumes.
Tube 1: 0.5 mL
Tube 2: 0.5 mL
Tube 3: 1.0 mL (contains antioxidants necessary to protect
the sample integrity)
Tube 4: 1.0 mL
Tube 5: 0.5 mL
- If samples not blood contaminated should be placed on dry
ice at bedside
- If samples are blood contaminated, the tubes should immediately
be centrifuged (prior to freezing) and the clear CSF transferred to
new similarly labeled tubes, then frozen.
-Store samples at -80 until they can be shipped.
2) Complete Medical Neurogenetics, LLC request form. Include
test required, sample date, date of birth, current medications
and relevant history.
3) Label tubes with patient name and ID number, leaving the tube
number viewable.
4) Place samples inside a specimen transport bag and the Medical
Neurogenetics, LLC request form inside the pouch of the transport
bag.
5) Ship samples frozen on dry ice.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Specimens other than | CSF in special collection kit (MML supply T657) |
| Anticoagulants other than | NA |
| Hemolysis | NA |
| Thawing | Warm reject; Cold reject |
| Lipemia | NA |
| Icteric | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| CSF | Frozen | |
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Age 5HIAA HVA 3-O-MD
(years) (nmol/L) (nmol/L) (nmol/L)
0-0.2 208-1159 337-1299 <300
0.2-0.5 179-711 450-1132 <300
0.5-2.0 129-520 294-1115 <300
2.0-5.0 74-345 233-928 <150
5.0-10 66-338 218-852 <100
10-15 67-189 167-563 <100
Adults 67-140 145-324 <100
Interpretation performed by Keith Hyland, Ph.D.
Note: If test results are inconsistent with the clinical
presentation, please call our laboratory to discuss the case
and/or submit a second sample for confirmatory testing.
DISCLAIMER required by the FDA for high complexity clinical
laboratories: HPLC testing was developed and its performance
characteristics determined by Medical Neurogenetics. These
HPLC tests have not been cleared or approved by the U.S. FDA.
Test Performed By: Medical Neurogenetics Lab
5424 Glenridge Drive NE
Atlanta, GA 30342
Interpretation Provides information to assist in interpretation of the test results
Recently, a cerebral folate deficiency syndrome has
been described. The clinical picture is one of
developmental delay/regression, cerebellar ataxia,
with or without seizures, with or without autism.
This disorder is treatable with folinic acid. If your
patient fits the clinical picture we can measure 5-
methyltetrahydrofolate in the CSF we already have if you
wish to add on this test. Please see: Ramaekers VT, Blau N.
Cerebral folate deficiency, Dev Med Child Neurol.
2004 Dec;46(12):843-51. Cerebral folate deficiency
has also been described in mitochondrial disorders.
We now have biomarkers for folinic acid/pyridoxine
responsive seizures (Antiquitin, ALDH7A1) that appear on
our neurotransmitter metabolite chromatogram.
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Performing Laboratory Location The location of the laboratory that performs the test
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
82492
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| Z0852 | 5-Hydroxyindoleacetic acid | 47544-2 |
| Z0849 | Homovanillic acid | 40846-8 |
| Z0850 | 3-O-methyldopa | 3496-7 |
| Z0851 | Interpretation: | In Process |
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