NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Evaluates the presence of antibodies to muscle-specific receptor
tyrosine kinase (MuSK)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
MuSK Quantitative Titers Antibody
Muscle Specific Receptor Tyrosine Kinase FORWARD
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Draw blood in plain red-top tube(s). (Serum gel tube is acceptable.)
Spin down and send 2 mL of serum refrigerated.
Note: Collection date is required.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Specimens other than
Anticoagulants other than
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
|Serum||Refrigerated (preferred)||14 days|
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Positive: > or = 20
Test Performed by: Athena Diagnostics
377 Plantation Street
Four Biotech Park
Worcester, MA 01605
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Neli B. et al. J. Neuroimmunology 2006: 177: 119-131.
2. Hoch, W. et al. Nature Medicine. 2001; 7:365-368.
3. Hopf, C. et al. Euro. J. Biochem. 1998; 253: 382-389.
4. Hopf, C. et al. J. Bio. Chem. 1998; 273: 6467-6473.
5. Husain, A. et al. Ann NY Acad Sci. 1998; 13:471-474.
6. Nakahama, Y. et al. Clinical Neurology. 2007: 47:356-8
Method Description Describes how the test is performed and provides a method-specific reference
Detection of MuSK associated antibodies was performed by
Radioimmunoassay (RIA) using highly purified MuSK recombinant
antigen. The use of purified recombinant antigen virtually eliminates
non-specific reactivity thereby reducing the likelihood of false
positive test results. Quantitation of anti-MuSK antibody expressed
as titer units is calculated from comparison of specimen serial
dilution to negative and elevated MuSK reference standards.
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
This test was developed and its performance characteristics determined by Athena Diagnostics, Inc. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes and should not be regarded as investigational or for research only. Athena Diagnostics is licensed under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) to perform high complexity clinical testing. Athena Diagnostics has performed assay validation studies and has developed its laboratory protocols and operating procedures in consultation with experts in the field and in accordance with the standards of the National Committee on Clinical Laboratory Standards (NCCLS).
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
83519 Immunoassay analyte, quantitative, by radioimmunoassay
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
|Result ID||Reporting Name||LOINC Code|
|Z0082||MuSK Antibody||In Process|