Test ID: FSEC
Secretin
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Method Name A short description of the method used to perform the test
Direct Radioimmunoassay (RIA)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Specimen Type Describes the specimen type needed for testing
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Collect 10 mL of blood in special tube containing G.I. Preservative
(MML supply number T125). Specimen should be separated and
3 mL plasma frozen as soon as possible.
Patient preparation:
1) Patient should be fasting 10-12 hours prior to collection.
2) Patient should not be on any antacid medication or
medications that affect gastroentero-intestinal function,
if possible, for at least 48 hours prior to collection.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Specimens other than | Plasma |
| Anticoagulants other than | Special GI preservative (MML supply T125) |
| Hemolysis | NA |
| Thawing | Warm reject; Cold reject |
| Lipemia | NA |
| Icteric | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| GI Plasma | Frozen | 30 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Secretin is a 27 amino acid basic peptide produced by S cells and
released by acid delivered into the duodenum. Secretin is released
into the blood when duodenal pH drops below 4. Secretin shares
structural similarity with Glucagon, Gastric Inhibitory Polypeptide,
Vasoactive Intestinal Polypeptide, PHIM, and Growth Hormone-
Releasing Hormone. Secretin is a potent stimulus for bicarbonate
secretion. Secretin also stimulates secretion of bile, release of Insulin,
and release of Gastric Pepsin in the stomach. Secretin inhibits Glucagon
release, intestinal motility, and prevents the uptake of water and sodium
ions by the intestine. In normal patients, Secretin has little effect on Gastrin
levels, but stimulates Gastrin greatly in Zollinger-Ellison patients. Secretin
is also elevated in Zollinger-Ellison patients and in patients with duodenal
ulcer. Secretin levels are low in patients with pernicious anemia and
achlorhydria. Secretin secretion can be suppressed by Somatostatin,
Cimetidine, and Methionine-Enkephalin.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
12-75 pg/mL (mean=25)
This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
Test Performed by: Inter Science Institute
944 West Hyde Park
Inglewood, CA 90302
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Friday
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
Performing Laboratory Location The location of the laboratory that performs the test
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
83519
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| Z0934 | Secretin | 2933-0 |
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