Test ID: ENAE
Antibody to Extractable Nuclear Antigen Evaluation, Serum
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
89035
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Yes
Useful For Suggests clinical disorders or settings where the test may be helpful
See individual unit codes.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SSA | SS-A/Ro Ab, IgG, S | Yes | Yes |
| SSB | SS-B/La Ab, IgG, S | Yes | Yes |
| SM | Sm Ab, IgG, S | Yes | Yes |
| RNP | RNP Ab, IgG, S | Yes | Yes |
| SCL70 | Scl 70 Ab, IgG, S | Yes | Yes |
| JO1 | Jo 1 Ab, IgG, S | Yes | Yes |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
See Connective Tissue Disease Cascade (CTDC) in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
Multiplex Flow Immunoassay
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Ab to Extractable Nuclear Ag Eval,S
Aliases Lists additional common names for a test, as an aid in searching
Anti-ENA (Antibodies to Extractable Nuclear Antigens)
Anti-La
Anti-Ribonuclear Protein
Anti-RNP (Anti-Ribonucleoprotein)
Anti-Ro
Anti-Sjogren's Syndrome
Anti-Sm (Smith)
Anti-Smith (SM) Antigen
Anti-SSA (Anti-Sjogren's Syndrome A)
Anti-SSB (Anti-Sjogren's Syndrome B)
Anti-U(1)RNP (Anti-Ribonucleoprotein)
Antibodies to Extractable Nuclear Antigens
Autoantibodies to Jo 1 Antigen
Autoantibodies to Sm (Smith)
Autoantibodies to SSA (Ro)
Autoantibodies to SSB (La)
Autoantibodies to U(1)RNP
Connective Tissue Disease Autoantibody Panel (2 tests)
DNA Topoisomerase 1 Antibodies
ENA (Extractable Nuclear Antigens), Anti
ENA/ADNA
Extractable Nuclear Antigens, Anti
Histidyl-tRNA Synthetase Antibodies
Immunology Profile (ENA)
Jo 1 Antibodies
LA (Anti-La)
La (Anti-SSB)
Polymyositis Antibodies
Ribonucleoprotein (RNP) Autoantibodies
RNP (Anti-RNP)
Ro (Anti-SSA)
Scl 70 Antibodies
Scleroderma Antibodies (? FOR SPECIFIC TEST)
Sjogren's Syndrome
Sm (Anti-Sm) (Smith)
Sm (Smith) Autoantibodies
Smith Antigen, Anti
SmRNP Autoantibodies
SSA (Anti-SSA)
SSB (Anti-SSB)
Topoisomerase 1 Antibodies
U(1)RNP (Ribonucleoprotein) Autoantibodies
Autoantibodies to Scl 70 Antigen
Anti-La
Anti-Ribonuclear Protein
Anti-RNP (Anti-Ribonucleoprotein)
Anti-Ro
Anti-Sjogren's Syndrome
Anti-Sm (Smith)
Anti-Smith (SM) Antigen
Anti-SSA (Anti-Sjogren's Syndrome A)
Anti-SSB (Anti-Sjogren's Syndrome B)
Anti-U(1)RNP (Anti-Ribonucleoprotein)
Antibodies to Extractable Nuclear Antigens
Autoantibodies to Jo 1 Antigen
Autoantibodies to Sm (Smith)
Autoantibodies to SSA (Ro)
Autoantibodies to SSB (La)
Autoantibodies to U(1)RNP
Connective Tissue Disease Autoantibody Panel (2 tests)
DNA Topoisomerase 1 Antibodies
ENA (Extractable Nuclear Antigens), Anti
ENA/ADNA
Extractable Nuclear Antigens, Anti
Histidyl-tRNA Synthetase Antibodies
Immunology Profile (ENA)
Jo 1 Antibodies
LA (Anti-La)
La (Anti-SSB)
Polymyositis Antibodies
Ribonucleoprotein (RNP) Autoantibodies
RNP (Anti-RNP)
Ro (Anti-SSA)
Scl 70 Antibodies
Scleroderma Antibodies (? FOR SPECIFIC TEST)
Sjogren's Syndrome
Sm (Anti-Sm) (Smith)
Sm (Smith) Autoantibodies
Smith Antigen, Anti
SmRNP Autoantibodies
SSA (Anti-SSA)
SSB (Anti-SSB)
Topoisomerase 1 Antibodies
U(1)RNP (Ribonucleoprotein) Autoantibodies
Autoantibodies to Scl 70 Antigen
Specimen Type Describes the specimen type needed for testing
Serum
Specimen Required Defines the optimal specimen. This field describes the type of specimen required to perform the test and the preferred volume to complete testing. The volume allows automated processing, fastest throughput and, when indicated, repeat or reflex testing.
Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 0.5 mL
Forms: If not ordering electronically, submit a General Request Form (Supply T239) with the specimen.
Specimen Minimum Volume Defines the amount of specimen required to perform an assay once, including instrument and container dead space. Submitting the minimum specimen volume makes it impossible to repeat the test or perform confirmatory or perform reflex testing. In some situations, a minimum specimen volume may result in a QNS (quantity not sufficient) result, requiring a second specimen to be collected.
0.35 mL
Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross reject |
| Lipemia | Mild OK; Gross reject |
| Icterus | Mild OK; Gross OK |
| Other | NA |
Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the laboratory. Alternate acceptable temperature(s) are also included.
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 21 days |
| Frozen | 21 days |
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
See individual unit codes.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
SS-A/Ro ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
SS-B/La ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
Sm ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
RNP ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
Scl 70 ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
Jo 1 ANTIBODIES, IgG
<1.0 U (negative)
> or =1.0 U (positive)
Reference values apply to all ages.
Interpretation Provides information to assist in interpretation of the test results
See individual unit codes.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
See individual unit codes.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
See individual unit codes.
Method Description Describes how the test is performed and provides a method-specific reference
See individual unit codes.
Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.
Monday through Saturday; 4 p.m., Sunday; 11 a.m.
Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.
Same day/1 day
Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Medical Laboratories until the release of the test result
2 days
Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
See individual unit codes.
Performing Laboratory Location The location of the laboratory that performs the test
Rochester
Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
86235 x 6
LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.
| Result ID | Reporting Name | LOINC Code |
|---|---|---|
| JO1 | Jo 1 Ab, IgG, S | 33571-1 |
| RNP | RNP Ab, IgG, S | 31588-7 |
| SCL70 | Scl 70 Ab, IgG, S | 47322-3 |
| SM | Sm Ab, IgG, S | 18323-6 |
| SSA | SS-A/Ro Ab, IgG, S | 33610-7 |
| SSB | SS-B/La Ab, IgG, S | 33613-1 |
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